Adrenaline-induced hypotension in the context of significant quetiapine overdose.

In patients presenting with hypotension due to significant quetiapine or mixed overdose, adrenaline should be avoided and consider medications such as noradrenaline or vasopressin as an alternative. If using noradrenaline peripherally, use a lower concentration (4 mg in 50 mL 5% glucose) and use a large bore cannula in a large vein.