母亲孕期体重增加模式与后代过敏性疾病的关联：一项前瞻性队列研究。

Patterns of maternal gestational weight gain in association with allergic diseases in offspring: A prospective cohort study.

作者信息

Lin Lixia, Chen Xi, Huang Li, Zhong Chunrong, Wu Meng, Wang Weiming, Wang Huanzhuo, Yang Sen, Cao Xiyu, Xiong Guoping, Yang Xuefeng, Hao Liping, Sun Guoqiang, Yang Nianhong

机构信息

Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Department of Obstetrics and Gynecology, The Central Hospital of Wuhan, Wuhan, China.

出版信息

BJOG. 2023 Aug;130(9):1038-1046. doi: 10.1111/1471-0528.17448. Epub 2023 Mar 20.

DOI:10.1111/1471-0528.17448

PMID:36938832

Abstract

OBJECTIVE

To evaluate the association between patterns of gestational weight gain (GWG) and allergic diseases in offspring.

DESIGN

Prospective cohort study.

SETTING

Prenatal clinics in Wuhan, China.

POPULATION

A cohort of 2546 mother and offspring pairs were enrolled before 16 weeks of gestation and followed up to 24 months postpartum.

METHODS

Maternal body weights were measured regularly during pregnancy, and their GWG patterns were estimated using the growth mixture model. Robust Poisson models were used to evaluate relative risk (RR) and 95% CI after multivariable adjustment.

MAIN OUTCOME MEASURES

Offspring atopic allergy and allergic contact dermatitis were defined according to a physician's diagnosis reported by the mother, and food allergy was reported by the mother.

RESULTS

Three GWG patterns were identified: 18.1% (461) of the women were described as pattern 1, characterised by rapid GWG earlier in pregnancy; 56.6% (1442) of the women were described as pattern 2, with steady GWG throughout pregnancy; and 25.3% (643) of the women was described as pattern 3, with rapid GWG later in pregnancy. By the age of 24 months, 360 (14.1%), 109 (4.3%) and 757 (29.7%) offspring had atopic allergy, allergic contact dermatitis or food allergy, respectively. Compared with women in GWG pattern 2, the RRs (95% CIs) among women in pattern 1 were 0.74 (0.55-0.99) for atopic allergy, 0.64 (0.36-1.15) for allergic contact dermatitis and 0.95 (0.81-1.12) for food allergy.

CONCLUSIONS

Maternal GWG pattern characterised by rapid GWG earlier in pregnancy was associated with a lower risk of atopic allergy in offspring.

摘要

目的

评估孕期体重增加（GWG）模式与子代过敏性疾病之间的关联。

设计

前瞻性队列研究。

地点

中国武汉的产前诊所。

研究对象

2546对母婴队列在妊娠16周前入组，并随访至产后24个月。

方法

孕期定期测量孕妇体重，并使用生长混合模型估计其GWG模式。采用稳健泊松模型在多变量调整后评估相对风险（RR）和95%置信区间（CI）。

主要观察指标

子代特应性过敏和过敏性接触性皮炎根据母亲报告的医生诊断定义，食物过敏由母亲报告。

结果

识别出三种GWG模式：18.1%（461名）女性被描述为模式1，其特征是孕期早期GWG快速增加；56.6%（1442名）女性被描述为模式2，孕期GWG稳定；25.3%（643名）女性被描述为模式3，孕期晚期GWG快速增加。到24个月龄时，分别有360名（14.1%）、109名（4.3%）和757名（29.7%）子代患有特应性过敏、过敏性接触性皮炎或食物过敏。与GWG模式2的女性相比，模式1女性中特应性过敏的RR（95%CI）为0.74（0.55 - 0.99），过敏性接触性皮炎为0.64（0.36 - 1.15），食物过敏为0.95（0.81 - 1.12）。