Department Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan, 430205, China.
Chem Biodivers. 2023 May;20(5):e202300172. doi: 10.1002/cbdv.202300172. Epub 2023 Apr 4.
Among the tetrahydroisoquinoline(THIQ) of natural products, a family of THIQ alkaloids has the characteristics of similar biosynthetic pathway. Such THIQ alkaloids family mainly include Renieramycins, Ecteinasicdins, Tetrazaomine, Lemonomycin, etc. Most of these natural compounds have strong antitumor activities, and its family member Ecteinasicdins743 (ET-743, Trabectedin) has been marketed in the European Union and the United States for the treatment of advanced soft tissue tumors and ovarian cancer. Because of the excellent biological activity and complex chemical structure of this kind of THIQ products, it has aroused great interest of biologists and chemists, and many synthetic chemists have paid considerable efforts to their total synthesis over the past decade. Based on this, the recent advances in the total synthesis of such THIQ alkaloids are reviewed.
在天然产物的四氢异喹啉（THIQ）中，一类四氢异喹啉生物碱具有相似的生物合成途径的特点。这类四氢异喹啉生物碱主要包括雷尼霉素、埃替非辛定、四氮杂环壬胺、莱莫尼霉素等。这些天然化合物大多数具有很强的抗肿瘤活性，其家族成员埃替非辛定 743（ET-743， trabectedin）已在欧盟和美国上市，用于治疗晚期软组织肿瘤和卵巢癌。由于这类 THIQ 产物具有优异的生物活性和复杂的化学结构，引起了生物学家和化学家的极大兴趣，在过去的十年中，许多合成化学家为其全合成付出了相当大的努力。基于此，本文综述了近年来这类四氢异喹啉生物碱的全合成进展。
