2 型糖尿病诊断年龄越早，与心血管疾病的遗传风险增加相关。

Earlier Age at Type 2 Diabetes Diagnosis Is Associated With Increased Genetic Risk of Cardiovascular Disease.

机构信息

1Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.

2Department of Translational Medicine, Seoul National University College of Medicine, Seoul, Korea.

出版信息

Diabetes Care. 2023 May 1;46(5):1085-1090. doi: 10.2337/dc22-2144.

DOI:10.2337/dc22-2144

PMID:36939558

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10154664/

Abstract

OBJECTIVE

We investigated genetic risk of cardiovascular disease (CVD) by age at type 2 diabetes (T2D) diagnosis.

RESEARCH DESIGN AND METHODS

We compared incident CVD events by age at T2D diagnosis using UK Biobank (N = 12,321) and the Seoul National University Hospital (SNUH) cohort (N = 1,165). Genetic risk was quantified using polygenic risk score (PRS).

RESULTS

Individuals with earlier T2D diagnosis had higher CVD risk. In UK Biobank, the effect size of coronary artery disease (CAD) PRS on incident CAD was largest in individuals diagnosed with T2D at ages 30-39 years (hazard ratio 2.25; 95% CI 1.56-3.26) and decreased as age at diagnosis increased: ages 40-49 (1.51; 1.30-1.75), 50-59 (1.36; 1.24-1.50), and 60-69 years (1.30; 1.14-1.48) (Pinteraction = 0.0031). A similar trend was observed in the SNUH cohort. This increased genetic risk associated with earlier T2D diagnosis was largely mitigated by a healthy lifestyle.

CONCLUSIONS

Individuals with an earlier T2D diagnosis have a higher genetic risk of CAD, and this information could be used to tailor lifestyle interventions.

摘要

目的

我们通过 2 型糖尿病（T2D）的发病年龄，研究心血管疾病（CVD）的遗传风险。

研究设计与方法

我们通过英国生物银行（N=12321）和首尔国立大学医院（SNUH）队列（N=1165），比较了不同 T2D 发病年龄的 CVD 事件发生率。使用多基因风险评分（PRS）量化遗传风险。

结果

T2D 发病年龄较早的个体 CVD 风险较高。在英国生物银行中，冠心病（CAD）PRS 对 CAD 发病的影响大小在 30-39 岁被诊断为 T2D 的个体中最大（危险比 2.25；95%CI 1.56-3.26），且随着发病年龄的增加而降低：40-49 岁（1.51；1.30-1.75）、50-59 岁（1.36；1.24-1.50）和 60-69 岁（1.30；1.14-1.48）（P 交互=0.0031）。SNUH 队列中也观察到了类似的趋势。与 T2D 发病较早相关的这种遗传风险增加，在很大程度上可通过健康的生活方式来减轻。