Banihashemian Abdolvahab, Benisi Soheila Zamanlui, Hosseinzadeh Simzar, Shojaei Shahrokh
Advanced Medical Sciences and Technologies Department, Faculty of Biomedical Engineering, Central Tehran Branch Islamic Azad University, Tehran, Iran.
Stem Cell Research Center, Tissue Engineering and Regenerative Medicine Institute, Tehran Central Branch, Islamic Azad University, Tehran, Iran.
Acta Histochem. 2023 Apr;125(3):152023. doi: 10.1016/j.acthis.2023.152023. Epub 2023 Mar 20.
Approaches to the design and construction of biomimetic scaffolds for osteochondral tissue, show increasing advances. Considering the limitations of this tissue in terms of repair and regeneration, there is a need to develop appropriately designed scaffolds. A combination of biodegradable polymers especially natural polymers and bioactive ceramics, shows promise in this field. Due to the complicated architecture of this tissue, biphasic and multiphasic scaffolds containing two or more different layers, could mimic the physiology and function of this tissue with a higher degree of similarity. The purpose of this review article is to discuss the approaches focused on the application of biphasic scaffolds for osteochondral tissue engineering, common methods of combining layers and the ultimate consequences of their use in patients were discussed.
用于骨软骨组织的仿生支架的设计和构建方法取得了越来越多的进展。考虑到该组织在修复和再生方面的局限性，有必要开发设计合理的支架。可生物降解聚合物，特别是天然聚合物与生物活性陶瓷的组合，在该领域显示出前景。由于该组织结构复杂，包含两个或更多不同层的双相和多相支架能够更高程度地模拟该组织的生理和功能。这篇综述文章的目的是讨论专注于双相支架在骨软骨组织工程中应用的方法、层组合的常用方法以及它们在患者中的最终应用效果。
