肌肉与脂肪比率与心脏代谢风险的关联：中国国家健康调查。

The association between muscle-to-fat ratio and cardiometabolic risks: The China National Health Survey.

机构信息

Department of Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, China.

Department of Chronic and Noncommunicable Disease Prevention and Control, Guizhou Provincial Center for Disease Control and Prevention, Guiyang, China.

出版信息

Exp Gerontol. 2023 May;175:112155. doi: 10.1016/j.exger.2023.112155. Epub 2023 Mar 20.

DOI:10.1016/j.exger.2023.112155

PMID:36940562

Abstract

BACKGROUND

The relationship between muscle mass and fat mass might be an indicator to assess the cardiometabolic risk independently from overweight/obesity, but evidence from a representative general Chinese population is lacking.

OBJECTIVE

To understand the age- and sex-specific associations between muscle-to-fat ratio (MFR) and cardiometabolic risks in Chinese population.

METHODS

31,178 (12,526 men and 18,652 women) subjects from the China National Health Survey were included. Muscle mass and fat mass were assessed by a bioelectrical impedance device. MFR was calculated as muscle mass divided by fat mass. Systolic blood pressure (SBP) and diastolic blood pressure (DBP), serum lipids, fasting plasma glucose and serum uric acid were measured. General linear regressions, quantile regressions and restricted cubic-spline (RCS) regressions were applied to assess the effect of MFR on cardiometabolic profiles.

RESULTS

Per unit increase of MFR was associated with a 0.631 (0.759-0.502) mmHg SBP decrease in men, 2.648 (3.073-2.223) in women; 0.480 (0.568-0.392) mmHg DBP decrease in men, 2.049 (2.325-1.774) in women; a 0.054 (0.062-0.046) mmol/L total cholesterol decrease in men, 0.147 (0.172-0.122) in women; 0.084 (0.098-0.070) mmol/L triglycerides decrease in men, 0.225 (0.256-0.194) in women; a 0.045 (0.054-0.037) mmol/L low-density lipoprotein decrease in men, 0.183 (0.209-0.157) in women; a 2.870 (2.235-3.506) μmol/L serum uric acid decrease in men, 13.352 (14.967-11.737) in women; and a 0.027 (0.020-0.033) mmol/L high-density lipoprotein increase in men, 0.112 (0.098-0.126) mmol/L in women. The effect in overweight/obese people was much significant than in under/normal weight counterparts. The RCS curves revealed both linear and non-linear relationships between increased MFR and lower cardiometabolic risk.

CONCLUSIONS

Muscle-to-fat ratio is independently associated with multiple cardiometabolic parameters among Chinese adults. Higher MFR is related with better cardiometabolic health, and the effect is much significant in overweight/obese people and women.

摘要

背景

肌肉量与脂肪量的关系可能是评估心血管代谢风险的一个指标，与超重/肥胖无关，但缺乏来自代表性的中国普通人群的证据。

目的

了解中国人群中肌肉与脂肪比值（MFR）与心血管代谢风险之间的年龄和性别特异性关联。

方法

纳入了来自中国国家健康调查的 31178 名（男性 12526 名，女性 18652 名）受试者。肌肉量和脂肪量通过生物电阻抗设备进行评估。MFR 计算为肌肉量除以脂肪量。测量收缩压（SBP）和舒张压（DBP）、血清脂质、空腹血糖和血清尿酸。应用一般线性回归、分位数回归和限制性立方样条（RCS）回归来评估 MFR 对心血管代谢特征的影响。

结果

MFR 每增加一个单位，男性的 SBP 降低 0.631（0.759-0.502）mmHg，女性降低 2.648（3.073-2.223）mmHg；男性 DBP 降低 0.480（0.568-0.392）mmHg，女性降低 2.049（2.325-1.774）mmHg；男性总胆固醇降低 0.054（0.062-0.046）mmol/L，女性降低 0.147（0.172-0.122）mmol/L；男性甘油三酯降低 0.084（0.098-0.070）mmol/L，女性降低 0.225（0.256-0.194）mmol/L；男性 LDL 降低 0.045（0.054-0.037）mmol/L，女性降低 0.183（0.209-0.157）mmol/L；男性血尿酸降低 2.870（2.235-3.506）μmol/L，女性降低 13.352（14.967-11.737）μmol/L；男性 HDL 升高 0.027（0.020-0.033）mmol/L，女性升高 0.112（0.098-0.126）mmol/L。超重/肥胖人群的效果明显强于正常/消瘦人群。RCS 曲线显示了增加 MFR 与降低心血管代谢风险之间的线性和非线性关系。