Zhongshan Hospital Institute of Clinical Science, Fudan University Shanghai Medical College, Shanghai, China.
Med Res Rev. 2023 Jul;43(4):1253-1258. doi: 10.1002/med.21944. Epub 2023 Mar 21.
Glycodrug is an important chemical medicine category derived from biological carbohydrates and their mimics. However, the fundamental logic and features of glycodrugs are obscure issues. To make it easier to understand, four key characters of glycodrugs are extracted for reference. First, Glc relating drugs are key guards in glycometabolism. Second, Rib, GlcN/GalN, and Sia relating drugs are efficient modulators in life signaling regulations. Third, rare sugar relating drugs are effective weapons against various pathogens. Finally, glycosylation modifications are helpful strategies for druggability enhancement. In light of such key characters, more innovative glycodrugs will emerge in the future.
糖药物是一类重要的化药,来源于生物糖及其类似物。然而,糖药物的基本逻辑和特征尚不清楚。为了便于理解,本文提取了糖药物的四个关键特征供参考。首先,与 Glc 相关的药物是糖代谢的关键守卫者。其次,与 Rib、GlcN/GalN 和 Sia 相关的药物是生命信号调节的有效调节剂。第三,稀有糖相关的药物是对抗各种病原体的有效武器。最后,糖基化修饰是提高成药性的有效策略。有鉴于此,未来将会涌现出更多创新的糖药物。