Detection of hazardous toxic gases for air pollution monitoring and medical diagnosis has attracted the attention of researchers in order to realize sufficiently sensitive gas sensors. In this paper, we fabricated and characterized a Titanium dioxide (TiO)-based gas sensor enhanced using the gold nanoparticles. Thermal oxidation and sputter deposition methods were used to synthesize fabricated gas sensor. X-ray diffraction analysis was used to determine the anatase structure of TiOsamples. It was found that the presence of gold nanoparticles on the surface of TiOenhances the sensitivity response of gas sensors by up to about 40%. The fabricated gas sensor showed a sensitivity of 1.1, 1.07 and 1.03 to 50 ppm of acetone, methanol and ethanol vapors at room temperature, respectively. Additionally, the gold nanoparticles reduce 50 s of response time (about 50% reduction) in the presence of 50 ppm ethanol vapor; and we demonstrated that the recovery time of the gold decorated TiOsensor is less than 40 s. Moreover, we explain that the improved performance depends on the adsorption-desorption mechanism, and the chemical sensitization and electronic sensitization of gold nanoparticles.