Department of Anesthesiology, Second Affiliated Hospital, Third Military Medical University, Chongqing, 400037, China.
Department of Anesthesiology, Yongchuan Hospital, Chongqing Medical University, Chongqing, 402160, China.
Adv Sci (Weinh). 2023 May;10(15):e2300189. doi: 10.1002/advs.202300189. Epub 2023 Mar 24.
Sevoflurane has been the most widely used inhaled anesthetics with a favorable recovery profile; however, the precise mechanisms underlying its anesthetic action are still not completely understood. Here the authors show that sevoflurane activates a cluster of urocortin 1 (UCN1 )/cocaine- and amphetamine-regulated transcript (CART ) neurons in the midbrain involved in its anesthesia. Furthermore, growth hormone secretagogue receptor (GHSR) is highly enriched in sevoflurane-activated UCN1 /CART cells and is necessary for sleep induction. Blockade of GHSR abolishes the excitatory effect of sevoflurane on UCN1 /CART neurons and attenuates its anesthetic effect. Collectively, their data suggest that anesthetic action of sevoflurane necessitates the GHSR activation in midbrain UCN1 /CART neurons, which provides a novel target including the nucleus and receptor in the field of anesthesia.
七氟醚是最广泛使用的吸入麻醉剂，具有良好的恢复特性；然而，其麻醉作用的确切机制仍不完全清楚。作者在这里表明，七氟醚激活了中脑中参与麻醉的一组促皮质素释放肽 1（UCN1）/可卡因和安非他命调节的转录物（CART）神经元。此外，生长激素促分泌素受体（GHSR）在七氟醚激活的 UCN1/CART 细胞中高度富集，是诱导睡眠所必需的。GHSR 阻断剂可消除七氟醚对 UCN1/CART 神经元的兴奋作用，并减弱其麻醉作用。总的来说，他们的数据表明，七氟醚的麻醉作用需要中脑 UCN1/CART 神经元中 GHSR 的激活，这为包括核和受体在内的麻醉领域提供了一个新的靶点。
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