Turk Psikiyatri Derg. 2023 Spring;34(1):60-64. doi: 10.5080/u27025.
Obsessive-compulsive symptoms induced by clozapine negatively affect treatment compliance. In some studies, clonazepam was shown to be beneficial in obsessive-compulsive disorder. However, in literature there are case reports of life-threatening complications associated with the combined use of clozapine and benzodiazepines. In this article, the efficacy and safety of the clonazepam augmentation were discussed in two patients who had obsessive-compulsive symptoms induced by clozapine. No life-threatening complications were detected during the follow-up period of more than two years, and the patients benefited dramatically from the addition of clonazepam. In treatment-resistant patients, clonazepam can be used with close monitoring for obsessivecompulsive symptoms associated with atypical antipsychotics. Keywords: Atypical antipsychotics, clonazepam, clozapine, obsessivecompulsive symptoms.
氯氮平引起的强迫症状会影响治疗依从性。一些研究表明，氯硝西泮对强迫症有益。然而，文献中有报道称，氯氮平和苯二氮䓬类药物联合使用会出现危及生命的并发症。在本文中，我们讨论了氯氮平增效治疗氯氮平引起的强迫症状的两例患者的疗效和安全性。在超过两年的随访期间，未发现危及生命的并发症，并且患者从氯氮平的添加中获益显著。对于治疗抵抗的患者，可以密切监测使用氯氮平治疗与非典型抗精神病药相关的强迫症。关键词：非典型抗精神病药，氯硝西泮，氯氮平，强迫症。
