人β-酪蛋白吗啡五肽基因的合成与克隆
Synthesis and cloning of a human beta-casomorphin-5 gene.
作者信息
Hoffmann S, Günther E, Kunze G, Bärwolff D, Teppke M, Barth A
机构信息
Martin Luther University, Department of Chemistry, Halle/S, GDR.
出版信息
Nucleic Acids Symp Ser. 1987(18):229-32.
PMID:3697133
Abstract
As so far a singularity among opioid peptides, bovine beta-casomorphin-5 has been shown to display pronounced cardiatic activities. The gene sequence of a human beta-casomorphin-5, including plasmid insertion and fusion protein expression and cleavage instrumentary, has been synthesized by a manual phosphoramidite procedure and cloned in a bacterial system.
摘要
作为迄今为止阿片样肽中的一个独特存在，牛β-酪蛋白吗啡-5已被证明具有显著的心脏活性。人β-酪蛋白吗啡-5的基因序列，包括质粒插入、融合蛋白表达和切割工具，已通过手动亚磷酰胺法合成并克隆到细菌系统中。
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