Department of Biotechnology, Sangmyung University, Seoul, 03016, South Korea.
School of Biological Sciences, AIPH University, Bhubaneswar, 752101, India.
Phytother Res. 2023 May;37(5):2067-2091. doi: 10.1002/ptr.7809. Epub 2023 Mar 27.
The ineffectiveness of traditional cancer therapies due to drug resistance, nontargeted delivery, and chemotherapy-associated adverse side effects has shifted attention to bioactive phytochemicals. Consequently, research efforts toward screening and identification of natural compounds with anticancer properties have increased in recent years. Marine seaweed-derived bioactive compounds, such as polyphenolic compounds, have exhibited anticancer properties. Phlorotannins (PTs), a major group of seaweed-derived polyphenolic compounds, have emerged as powerful chemopreventive and chemoprotective compounds, regulating apoptotic cell death pathways both in vitro and in vivo. In this context, this review focuses on the anticancer activity of polyphenols isolated from brown algae, with a special reference to PTs. Furthermore, we highlight the antioxidant effects of PTs and discuss how they can impact cell survival and tumor development and progression. Moreover, we discussed the potential therapeutic application of PTs as anticancer agents, having molecular mechanisms involving oxidative stress reduction. We have also discussed patents or patent applications that apply PTs as major components of antioxidant and antitumor products. With this review, researcher may gain new insights into the potential novel role of PTs, as well as uncover a novel cancer-prevention mechanism and improve human health.
由于耐药性、非靶向递送和化疗相关的不良反应，传统癌症疗法的效果不佳，因此人们将注意力转向了具有生物活性的植物化学物质。近年来，人们加大了对具有抗癌特性的天然化合物的筛选和鉴定研究力度。海洋海藻来源的生物活性化合物，如多酚类化合物，已经表现出抗癌特性。海藻多酚中的一类主要化合物——岩藻多酚（PTs），已成为强大的化学预防和化学保护化合物，在体外和体内调节细胞凋亡死亡途径。在这种情况下，本综述重点介绍了从褐藻中分离出的多酚的抗癌活性，特别是 PTs。此外，我们强调了 PTs 的抗氧化作用，并讨论了它们如何影响细胞存活和肿瘤的发生和发展。此外，我们还讨论了 PTs 作为抗癌药物的潜在治疗应用，其分子机制涉及降低氧化应激。我们还讨论了将 PTs 作为抗氧化和抗肿瘤产品主要成分的专利或专利申请。通过这项综述，研究人员可能会对 PTs 的潜在新作用有新的认识，并发现新的癌症预防机制，从而改善人类健康。
