Northwest ZooPath, Monroe, WA 98272, USA,
White Oak Conservation, Yulee, FL 32097, USA.
J Zoo Wildl Med. 2023 Mar;54(1):102-110. doi: 10.1638/2021-0166.
Over a span of 6 yr, six adult eastern bongo antelope () from a single institution died due to systemic mycotic infections. All animals were of the same genetic lineage and in good body condition at the time of death. Gross findings in all cases included multifocal white-to-tan nodules up to 10 cm in diameter that were most numerous in the heart, lung, and kidney. Histologic examination identified these nodules as foci of granulomatous inflammation containing branching, septate, broad, undulating fungal elements. Identification of the fungal species was pursued using PCR with sequencing, immunohistochemistry, and culture. Multiple fungal species were identified using the various modalities, and commonality of species identification was limited to sp. in four of the cases. The clinical and postmortem findings in these cases were identical and were considered to be the same infectious disease. The sp. was considered a candidate as an emerging fatal infectious agent in this population of bongo antelopes. In all of these cases, death was attributed to conduction abnormalities associated with the cardiac lesions or euthanasia.
在 6 年的时间里,来自同一机构的 6 只成年东部大羚羊()因全身性真菌感染而死亡。所有动物在死亡时都属于同一遗传谱系,身体状况良好。所有病例的大体检查结果均包括直径达 10 厘米的多发性白色至棕褐色小结节,这些结节在心脏、肺和肾脏中最为常见。组织学检查将这些结节确定为含有分枝、分隔、宽阔、波浪状真菌的肉芽肿性炎症灶。使用 PCR 测序、免疫组织化学和培养法对真菌种类进行了鉴定。使用各种方法鉴定出了多种真菌,仅在其中 4 例中鉴定出了 sp. 。这些病例的临床和尸检结果相同,被认为是同种传染病。 sp. 被认为是该大羚羊种群中一种新出现的致命感染因子的候选者。在所有这些情况下,死亡归因于与心脏病变相关的传导异常或安乐死。