Department of Public Health, Woldia University, Woldia, Ethiopia.
Department of Public Health, Debre Markos University, Debre Markos, Ethiopia.
Pharmacoepidemiol Drug Saf. 2023 Sep;32(9):978-987. doi: 10.1002/pds.5625. Epub 2023 Apr 20.
Acquired immune deficiency syndrome (AIDS) becomes a manageable chronic disease due to the presence of effective prevention, diagnosis, treatment, and care accesses. Viral load cascade analyses are important to identify gaps in human immunodeficiency virus (HIV)/AIDS treatment and care for quality improvements.
Time to Virological Failure and its Predictors among HIV Infected Individuals on Second Line Antiretroviral Treatment (SLART) in North-East Ethiopia, 2021.
Institution-based retrospective follow-up study was conducted on 474 HIV-infected individuals who were on SLART between September 2016 and April 2020. A universal sampling technique was used to recruit study participants. Data were entered by EpiData-3.3.1 and analyzed by STATA-14. Cox proportional hazard assumptions were checked to determine the effect of predictor variables on virological failure (VF). The study was conducted from February 1 to April 30, 2021.
The rate of VF in this study was 15.4% with an incidence rate of 4.93 per 100 person-years. As participants' age and duration of ART use increased by 1 year the hazards of VF was reduced by 2.9% (AHR: 0.971, 95% CI: 0.945, 0.995) and 10.6% (AHR: 0.894, 95% CI: 0.828, 0.963), respectively. The hazards of VF were twice higher among those who were on a non-protease inhibitor-based regimen. Individuals who had a history of making enhanced adherence counseling (EAC) sessions during SLART had three times more risk to develop VF (AHR: 3.374, 95% CI: 1.790, 6.361).
The rate of VF among SLART users was high. Keeping SLART users on PI-based regimens may improve virological outcomes in HIV care and treatment. Making EAC sessions effective in promoting better ART adherence might reduce VF.
由于有效的预防、诊断、治疗和护理途径的存在，艾滋病（AIDS）已成为一种可控制的慢性疾病。病毒载量级联分析对于确定艾滋病毒（HIV）/艾滋病治疗和护理中的差距以进行质量改进非常重要。
2021 年，在埃塞俄比亚东北部，接受二线抗逆转录病毒治疗（SLART）的 HIV 感染者中病毒学失败的时间及其预测因素。
对 2016 年 9 月至 2020 年 4 月期间接受 SLART 的 474 名 HIV 感染者进行了基于机构的回顾性随访研究。使用普遍抽样技术招募研究参与者。数据由 EpiData-3.3.1 录入，由 STATA-14 进行分析。检查 Cox 比例风险假设，以确定预测变量对病毒学失败（VF）的影响。该研究于 2021 年 2 月 1 日至 4 月 30 日进行。
本研究的 VF 发生率为 15.4%，发病率为每 100 人年 4.93 例。随着参与者年龄和抗逆转录病毒治疗（ART）使用时间的增加 1 年，VF 的风险降低了 2.9%（AHR：0.971，95%CI：0.945，0.995）和 10.6%（AHR：0.894，95%CI：0.828，0.963）。接受非蛋白酶抑制剂为基础的方案治疗的患者发生 VF 的风险增加了一倍。在 SLART 期间接受过增强型依从性咨询（EAC）的患者发生 VF 的风险增加了三倍（AHR：3.374，95%CI：1.790，6.361）。
SLART 使用者的 VF 发生率很高。让 SLART 使用者坚持使用基于蛋白酶抑制剂的方案可能会改善 HIV 护理和治疗中的病毒学结果。使 EAC 课程在促进更好的抗逆转录病毒药物依从性方面发挥有效作用，可能会降低 VF。
