Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.
Technol Cancer Res Treat. 2022 Jan-Dec;21:15330338221117402. doi: 10.1177/15330338221117402.
Breast cancer is a kind of malignant tumor that seriously endangers women's life and health. Once diagnosed, most patients will receive a combination of treatments to achieve a cure. However, breast cancer is a heterogeneous disease. Even with the same clinical stage and pathological features, its response to treatment and postoperative recurrence risk may still be completely different. With the advent of genomic assay, some patients with early-stage breast cancer who originally needed treatment can still achieve long-term disease-free survival without adjuvant chemotherapy, so as to achieve personalized and accurate treatment mode to a certain extent. In this paper, we reviewed the 5 most widely used and studied genomic panel technologies in breast cancer, namely , , , and , according to accessibility and availability. Based on the results of the completed or ongoing clinical studies, we summarized the origin, applicable population, and clinical efficacy of each detection method, and discussed the potential development prospect of detection technology in the future.
乳腺癌是一种严重危害妇女生命健康的恶性肿瘤。一旦确诊，大多数患者将接受多种治疗方法的联合治疗，以实现治愈。然而，乳腺癌是一种异质性疾病。即使具有相同的临床分期和病理特征，其对治疗的反应和术后复发风险仍可能完全不同。随着基因组检测技术的出现，一些原本需要治疗的早期乳腺癌患者仍然可以通过不接受辅助化疗而实现长期无病生存，从而在一定程度上实现了个性化和精准治疗模式。本文根据可及性和可用性，综述了乳腺癌中最广泛使用和研究的 5 种基因组panel 技术，即 、 、 、 、 。基于已完成或正在进行的临床研究结果，总结了每种检测方法的起源、适用人群和临床疗效，并讨论了检测技术未来的潜在发展前景。
