Wiggins R C, Delaney A C, Samorajski T
Brain Res. 1986 Mar 19;368(2):277-86. doi: 10.1016/0006-8993(86)90572-x.
Rats were postnatally undernourished during the suckling period (up to 20 days) and the brainstems of the perfused rats were dissected and prepared for electronmicroscopy at 21, 35 and 63 days of age. The effects on myelin were relatively mild and consisted primarily of a slight reduction in the relative numbers of myelinated fibers, most likely caused by a lag in the rate of loss of non-myelinated fibers, and fewer lamellae in myelinated axons of less than 2.5 micron circumference. Organelles were examined in the interfasicular oligodendroglia and in paragigantocellular reticular neurons immediately dorsal to the pyramidal tract. The numbers of mitochondrial particles in neuronal perikarya were significantly increased by postnatal undernourishment, although the numbers of other organelles appeared normal. Increased numbers of mitochondria persisted in nutritionally rehabilitated rats. Mitochondrial particles in oligodendroglia were not altered.
在哺乳期（直至20日龄）对大鼠进行出生后营养不良处理，在21日龄、35日龄和63日龄时，对灌注大鼠的脑干进行解剖并制备用于电子显微镜检查的样本。对髓鞘的影响相对较轻，主要表现为有髓纤维的相对数量略有减少，这很可能是由于无髓纤维损失速率的滞后导致的，并且在周长小于2.5微米的有髓轴突中髓鞘板层较少。在束间少突胶质细胞以及紧邻锥体束背侧的巨细胞旁网状神经元中检查细胞器。出生后营养不良显著增加了神经元胞体中线粒体颗粒的数量，尽管其他细胞器的数量看起来正常。在营养恢复的大鼠中，线粒体数量持续增加。少突胶质细胞中的线粒体颗粒没有改变。
