School of Public Health, Shandong University, Jinan 250012, China.
Department of Poisoning and Occupational Diseases, Emergency Medicine, Qilu Hospital of Shandong University, Jinan 250012, China.
Int J Environ Res Public Health. 2023 Mar 12;20(6):5021. doi: 10.3390/ijerph20065021.
Aluminum phosphide is a highly effective insecticide for fumigation in granaries and is often used in rural grain storage. However, people's awareness of its toxicity is not strong. A case of acute inhalation toxicity of phosphine caused by the use of aluminum phosphide to fumigate a granary is reported here. The case presented with aspiration pneumonia and acute left heart failure. The patient was cured using comprehensive life support treatment, including respiratory support, antiarrhythmic treatment, and blood pressure maintenance with vasoactive drugs. There is no specific antidote for phosphine poisoning at present, and the comprehensive application of restricted fluid resuscitation, high-dose glucocorticoid shock, vasoactive drugs and bedside hemofiltration is significant in improving the prognosis of patients. It is also important to remind people to pay attention to their own protection in the process of using aluminum phosphide.
磷化铝是一种高效的储粮熏蒸杀虫剂,常用于农村粮食储存。然而,人们对其毒性的认识并不强。本文报道了 1 例因使用磷化铝熏蒸粮仓而导致急性吸入性磷化氢中毒的病例。该病例表现为吸入性肺炎和急性左心衰竭。患者采用呼吸支持、抗心律失常治疗以及血管活性药物维持血压等综合生命支持治疗后痊愈。目前尚无磷化氢中毒的特效解毒剂,限制液体复苏、大剂量糖皮质激素冲击、血管活性药物及床边血液滤过的综合应用对改善患者预后具有重要意义。在使用磷化铝的过程中提醒人们注意自身保护也很重要。