Leffler C W, Hessler J R
Eur J Pharmacol. 1979 Feb 15;54(1-2):37-42. doi: 10.1016/0014-2999(79)90405-9.
Effects of PGI2 upon pulmonary vascular resistance and systemic arterial pressure of near term fetuses were evaluated in anesthetized, exteriorized, unventilated fetal lambs by means of an open-chest, pump-perfused lung preparation. These effects were compared to those of PGE1 and PGE2 in the same animals. Intrapulmonary arterial infusions of PGI2 produced dose-dependent decreases in pulmonary vascular resistance and systemic arterial pressure. Effects of PGI2 upon pulmonary vascular resistance are intermediate with respect to those of PGE1 (greater) and PGE2 (less). PGI2 is a potent hypotensive compound when administered to fetal lambs, producing dose-dependent decreases in systemic arterial pressure. When the three prostaglandins are infused into the pulmonary artery, effects on systemic arterial pressure of PGE1 and PGI2 are nearly identical. Effects of PGE2 are considerably less. PGI2 is a potent dilator of fetal lamb vessels and could play a role in circulatory control during perinatal transition.
通过开胸、泵灌注肺制备方法，在麻醉、体外化、未通气的近足月胎羊中评估前列环素（PGI2）对肺血管阻力和全身动脉压的影响。将这些影响与同一动物中前列腺素E1（PGE1）和前列腺素E2（PGE2）的影响进行比较。肺内动脉输注PGI2可使肺血管阻力和全身动脉压呈剂量依赖性降低。PGI2对肺血管阻力的影响介于PGE1（较大）和PGE2（较小）之间。当给胎羊注射PGI2时，它是一种有效的降压化合物，可使全身动脉压呈剂量依赖性降低。当将这三种前列腺素注入肺动脉时，PGE1和PGI2对全身动脉压的影响几乎相同。PGE2的影响则小得多。PGI2是胎羊血管的有效扩张剂，可能在围产期过渡期间的循环控制中发挥作用。
