Ikeda Naoto, Imao Takeshi, Hisano Yuki, Kamao Takayuki, Uno Masatoshi, Mizushima Takaaki
Department of Internal Medicine, Kaneda Hospital.
Rinsho Ketsueki. 2023;64(2):130-132. doi: 10.11406/rinketsu.64.130.
Lymphoblastic lymphoma (LBL) is a rare hematologic malignancy that originates from immature lymphocytes and usually expresses terminal deoxynucleotidyl transferase (TdT). Here, we report a case of TdT-negative B-LBL. A 71-year-old male patient presented to a hospital with shortness of breath. His chest computed tomography showed a mediastinal mass. Tumor cells did not express TdT but expressed MIC2, which led to LBL diagnosis. MIC2 is a useful marker for LBL diagnosis.
淋巴母细胞淋巴瘤(LBL)是一种罕见的血液系统恶性肿瘤,起源于未成熟淋巴细胞,通常表达末端脱氧核苷酸转移酶(TdT)。在此,我们报告一例TdT阴性的B-LBL病例。一名71岁男性患者因呼吸急促入院。他的胸部计算机断层扫描显示纵隔肿块。肿瘤细胞不表达TdT,但表达MIC2,从而确诊为LBL。MIC2是LBL诊断的有用标志物。