Murakami Keishu, Kanzaki Kazunori, Kajimoto Yoshinori, Ito Hidefumi
Department of Neurology, Wakayama Rosai Hospital.
Department of Neurology, Shingu Municipal Medical Center.
Rinsho Shinkeigaku. 2023 Apr 25;63(4):225-230. doi: 10.5692/clinicalneurol.cn-001818. Epub 2023 Mar 29.
We present varicella-zoster virus (VZV) infection with concomitant lower cranial polyneuropathy in the absence of meningeal symptoms. Physical examination showed involvement of cranial nerves IX and X in Case 1 and of cranial nerves IX, X, and XI in Case 2. Cerebrospinal fluid (CSF) analysis revealed mild lymphocytic pleocytosis, normal protein levels, and absence of VZV-DNA based on polymerase chain reaction (PCR) analysis. Serum anti-VZV antibody testing showed positive results in both cases, which confirmed the diagnosis of VZV infection. VZV infection accompanied by lower cranial polyneuropathy is rare; therefore, it is important to consider VZV reactivation as an etiopathogenetic contributor to pharyngeal palsy and hoarseness. We emphasize the importance of serological analysis for precise diagnosis in VZV infection with multiple lower cranial nerve palsies because the VZV-DNA PCR test may show negative results in patients without meningitis symptoms or in those with normal CSF protein levels.
我们报告了在无脑膜症状情况下出现水痘-带状疱疹病毒(VZV)感染并伴有低位颅神经多发性神经病的病例。体格检查显示,病例1累及第IX和第X颅神经,病例2累及第IX、第X和第XI颅神经。脑脊液(CSF)分析显示轻度淋巴细胞增多、蛋白水平正常,基于聚合酶链反应(PCR)分析未检测到VZV-DNA。血清抗VZV抗体检测在两例中均呈阳性,这证实了VZV感染的诊断。伴有低位颅神经多发性神经病的VZV感染很罕见;因此,将VZV再激活视为咽麻痹和声音嘶哑的病因学因素很重要。我们强调血清学分析对于精确诊断伴有多条低位颅神经麻痹的VZV感染的重要性,因为VZV-DNA PCR检测在没有脑膜炎症状或CSF蛋白水平正常的患者中可能呈阴性结果。