间变性大细胞淋巴瘤ALK阳性变异型原发性骨淋巴瘤伴黑色素瘤。
Anaplastic large cell lymphoma ALK-positive variant of primary bone lymphoma associated with melanoma.
作者信息
Tutaeva Victoria V, Ovsiannikova Maria R, Bobin Alexander N, Gorbunov Alexey V, Kurbanov Sergey I, Rukavitsin Oleg A
机构信息
Department of Hematology, The Main Military Clinical Hospital Named After N.N. Burdenko, Moscow 105094, Russia.
Department of Pathology, The Main Military Clinical Hospital Named After N.N. Burdenko, Moscow 105094, Russia.
出版信息
Oxf Med Case Reports. 2023 Mar 25;2023(3):omad025. doi: 10.1093/omcr/omad025. eCollection 2023 Mar.
We describe in detail a case of the anaplastic large cell lymphoma (ALCL) type of primary bone lymphoma, which initially was diagnosed and treated as osteomyelitis. The diagnosis was delayed because of unspecific clinical symptoms and uncertain radiographs and histology. Only relapse of the lymphoma from the same area with involvement of the soft tissue and local lymph nodes allowed to establish a correct diagnosis and start treatment. Also, in this case, we observed the development of the second cancer (melanoma), which has the same cytogenetic abnormality as ALCL (t[2;5]).
我们详细描述了一例原发性骨淋巴瘤的间变性大细胞淋巴瘤（ALCL）类型，该病例最初被诊断为骨髓炎并接受了相应治疗。由于临床症状不具特异性、X线片及组织学检查结果不明确，诊断被延误。只有当淋巴瘤从同一区域复发并累及软组织和局部淋巴结时，才得以确立正确诊断并开始治疗。此外，在该病例中，我们还观察到了第二种癌症（黑色素瘤）的发生，其具有与ALCL相同的细胞遗传学异常（t[2;5]）。
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