Department of Medicine, College of Medicine and Health Sciences, An-Najah National University, Nablus, 44839, Palestine.
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, 44839, Palestine.
Sci Rep. 2023 Mar 31;13(1):5293. doi: 10.1038/s41598-023-32648-8.
End-stage renal disease (ESRD) is a common chronic disease worldwide that requires hemodialysis. Patients may face chronic pain and poor quality of life. Therefore, a better understanding of these variables in hemodialysis patients is essential to provide a good intervention. We aim to determine how common chronic pain is in hemodialysis patients and its correlation with sociodemographics, C-reactive protein (CRP), calcium, phosphorus, albumin, and parathyroid hormone. A cross-sectional study of hemodialysis patients was conducted in Palestine. Data collection took place between November 2020 and May 2021. We used the brief pain inventory score to assess chronic pain, and lab tests detected CRP levels. Data were collected using a convenience sampling technique. There were two hundred sixty-one patients in the present study. The mean age of the patients was 51 years, with 63.6% being men. 47.1% of them reported having chronic pain. Gender (p = 0.011), social status (p = 0.003), educational status (p = 0.010), and number of chronic diseases (p = 0.004) indicated a significant relationship with the severity score of pain. Furthermore, sex (p = 0.011), social status (p = 0.003), and number of chronic diseases (p = 0.002) were significantly associated with the pain interference score. Additionally, Person's test indicated significant correlations between CRP and pain severity (p < 0.001) and with pain interference (p < 0.001). Albumin was significantly and negatively correlated with pain severity (p = 0.001) and pain interference (p < 0.001). Multiple linear regression analysis revealed that patients who had a higher CRP level and many chronic diseases were more likely to have a higher pain severity score. However, pain severity was the only predictor for pain interference. Our results suggest that there is a significant correlation between the existence of chronic pain in hemodialysis patients and increased CRP levels. However, further investigations are needed with a larger number of patients in more than one dialysis unit to confirm this correlation and management of chronic pain in patients with HD.
终末期肾病（ESRD）是一种常见的全球慢性疾病，需要进行血液透析。患者可能面临慢性疼痛和生活质量下降的问题。因此，更好地了解血液透析患者的这些变量对于提供良好的干预措施至关重要。我们旨在确定血液透析患者中常见的慢性疼痛及其与社会人口统计学、C 反应蛋白（CRP）、钙、磷、白蛋白和甲状旁腺激素的相关性。在巴勒斯坦进行了一项血液透析患者的横断面研究。数据收集于 2020 年 11 月至 2021 年 5 月之间。我们使用简明疼痛量表评估慢性疼痛，实验室检测检测 CRP 水平。数据采用便利抽样技术收集。本研究共有 261 名患者。患者的平均年龄为 51 岁，其中 63.6%为男性。47.1%的患者报告有慢性疼痛。性别（p=0.011）、社会地位（p=0.003）、教育程度（p=0.010）和慢性疾病数量（p=0.004）与疼痛严重程度评分显著相关。此外，性别（p=0.011）、社会地位（p=0.003）和慢性疾病数量（p=0.002）与疼痛干扰评分显著相关。此外，Person 检验表明 CRP 与疼痛严重程度（p<0.001）和疼痛干扰（p<0.001）之间存在显著相关性。白蛋白与疼痛严重程度（p=0.001）和疼痛干扰（p<0.001）呈显著负相关。多元线性回归分析显示，CRP 水平较高和患有多种慢性疾病的患者更有可能出现较高的疼痛严重程度评分。然而，疼痛严重程度是疼痛干扰的唯一预测因子。我们的结果表明，血液透析患者中慢性疼痛的存在与 CRP 水平升高之间存在显著相关性。然而，需要在更多的透析单位中进行更多的研究，以确认这一相关性并管理血液透析患者的慢性疼痛。
