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胰腺创伤的诊断与治疗。

Diagnosis and treatment of pancreatic trauma.

机构信息

Cátedra de Medicina Intensiva, Centro de Tratamiento Intensivo del Hospital de Clínicas, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.

Cátedra de Medicina Intensiva, Centro de Tratamiento Intensivo del Hospital de Clínicas, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.

出版信息

Med Clin (Barc). 2023 May 26;160(10):450-455. doi: 10.1016/j.medcli.2023.03.002. Epub 2023 Mar 31.

Abstract

Pancreatic trauma is a rare but potentially lethal entity which requires a high level of clinical suspicion. Early diagnosis and assessment of the integrity of the pancreatic duct are essential since ductal injury is a crucial predictor of morbimortality. Overall mortality is 19%, which can rise to 30% in cases of ductal injury. The diagnostic and therapeutic approach is multidisciplinary and guided by a surgeon, imaging specialist and ICU physician. Laboratory analysis shows that pancreatic enzymes are frequently elevated, which is a low specificity finding. In hemodynamically stable patients, the posttraumatic condition of the pancreas is firstly evaluated by the multidetector computed tomography. Moreover, in case of suspicion of ductal injury, more sensitive studies such as Endoscopic Retrograde Cholangiopancreatography or cholangioresonance are needed. This narrative review aims to analyze the etiopathogenesis and pathophysiology of pancreatic trauma and discuss its diagnosis and treatment. Also, the most clinically relevant complications will be summarized.

摘要

胰腺创伤较为罕见,但具有潜在致命性,需要高度的临床怀疑。早期诊断和评估胰管完整性至关重要,因为胰管损伤是病死率的关键预测因素。总体死亡率为 19%,在发生胰管损伤的情况下,死亡率可上升至 30%。诊断和治疗方法是多学科的,由外科医生、影像专家和重症监护医生共同指导。实验室分析显示,胰腺酶经常升高,但特异性较低。在血流动力学稳定的患者中,胰腺的创伤后情况首先通过多排螺旋 CT 进行评估。此外,在怀疑胰管损伤的情况下,需要进行更敏感的检查,如内镜逆行胰胆管造影或磁共振胆胰管成像。本综述旨在分析胰腺创伤的病因发病机制和病理生理学,并讨论其诊断和治疗方法。此外,还将总结最具临床相关性的并发症。

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