子痫前期的血管及肾脏机制
VASCULAR AND RENAL MECHANISMS OF PREECLAMPSIA.
作者信息
Wang Xi, Shields Corbin A, Ekperikpe Ubong, Amaral Lorena M, Williams Jan Michael, Cornelius Denise C
机构信息
Department of Pharmacology, University of Mississippi Medical Center.
Department of Emergency Medicine, University of Mississippi Medical Center.
出版信息
Curr Opin Physiol. 2023 Jun;33. doi: 10.1016/j.cophys.2023.100655. Epub 2023 Mar 2.
Preeclampsia (PE) is a multisystem obstetric disorder that affects 2-10% of pregnancies worldwide and it is a leading cause of maternal and fetal morbidity and mortality. The etiology of PE development is not clearly delineated, but since delivery of the fetus and placenta often leads to symptom resolution in the most cases of PE, it is hypothesized that the placenta is the inciting factor of the disease. Current management strategies for PE focus on treating the maternal symptoms to stabilize the mother in an attempt to prolong the pregnancy. However, the efficacy of this management strategy is limited. Therefore, identification of novel therapeutic targets and strategies is needed. Here, we provide a comprehensive overview of the current state of knowledge regarding mechanisms of vascular and renal pathophysiology during PE and discuss potential therapeutic targets directed at improving maternal vascular and renal function.
子痫前期（PE）是一种多系统产科疾病，影响全球2% - 10%的妊娠，是孕产妇和胎儿发病及死亡的主要原因。PE发生的病因尚未明确界定，但由于在大多数PE病例中，胎儿和胎盘娩出后症状往往会缓解，因此推测胎盘是该疾病的诱发因素。目前PE的管理策略侧重于治疗母体症状以稳定母亲状况，试图延长孕期。然而，这种管理策略的疗效有限。因此，需要确定新的治疗靶点和策略。在此，我们全面概述了目前关于PE期间血管和肾脏病理生理学机制的知识现状，并讨论旨在改善母体血管和肾脏功能的潜在治疗靶点。
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