Division of Population Health and Genomics, School of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK.
Department of Endocrinology and Diabetes, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK.
J Clin Endocrinol Metab. 2023 Sep 18;108(10):e1117-e1124. doi: 10.1210/clinem/dgad201.
Previous studies, including our own, have demonstrated a highly variable incidence of primary hyperparathyroidism (PHPT) from year to year.
We planned to provide a current estimate of the incidence and prevalence of PHPT in a community-based study.
A population-based retrospective follow-up study was conducted in Tayside (Scotland) from 2007 to 2018. Record-linkage technology (demography, biochemistry, prescribing, hospital admissions, radiology, and mortality data) was used to identify all patients. Cases of PHPT were defined as those with at least 2 raised serum corrected calcium concentration CCA (> 2.55 mmol/L) and/or hospital admissions with PHPT diagnoses and/or surgery records with parathyroidectomy during the follow-up period. The number of prevalent and incident cases of PHPT per calendar year by age and sex were estimated.
A total of 2118 people (72.3% female, mean age 65 years) were identified with an incident case of PHPT. The overall prevalence of PHPT over the 12 years of the study was 0.84% (95% CI, 0.68%-1.02%), steadily increasing from 0.71% in 2007 to 1.02% in 2018. From 2008, the incidence of PHPT was relatively stable from 4 to 6 cases per 10 000 person-years, declining from 11.5 per 10 000 person-years in 2007. The incidence varied from 0.59 per 10 000 person-years (95% CI, 0.40%-0.77%) for those aged 20 to 29 years, to 12.4 per 10 000 person-years (95% CI, 11.2%-13.3%) in those aged 70 to 79 years. Incidence of PHPT was 2.5 times higher in women than in men.
This study is the first showing a relatively steady annual incidence of PHPT at 4 to 6 per 10 000 person-years. This population-based study reports a PHPT prevalence of 0.84%.
既往研究，包括我们的研究，已经证实原发性甲状旁腺功能亢进症（PHPT）的发病率在逐年变化。
我们计划在一项基于社区的研究中提供 PHPT 发病率和患病率的最新估计值。
2007 年至 2018 年，在泰赛德（苏格兰）进行了一项基于人群的回顾性随访研究。使用记录链接技术（人口统计学、生物化学、处方、住院、放射学和死亡率数据）来识别所有患者。PHPT 病例定义为至少有 2 次血清校正钙浓度 CCA 升高（>2.55mmol/L）和/或在随访期间有 PHPT 诊断的住院记录和/或甲状旁腺切除术的手术记录。按年龄和性别估算每年新发病例和现患病例的数量。
共确定了 2118 例（72.3%为女性，平均年龄 65 岁）PHPT 新发病例。在研究的 12 年中，PHPT 的总体患病率为 0.84%（95%CI，0.68%-1.02%），从 2007 年的 0.71%稳步上升至 2018 年的 1.02%。从 2008 年开始，PHPT 的发病率相对稳定，每 10000 人年有 4 至 6 例，从 2007 年的每 10000 人年 11.5 例下降。发病率从 20 至 29 岁年龄组的 0.59/10000 人年（95%CI，0.40%-0.77%）到 70 至 79 岁年龄组的 12.4/10000 人年（95%CI，11.2%-13.3%）不等。女性的 PHPT 发病率是男性的 2.5 倍。
本研究首次显示，PHPT 的年发病率相对稳定，约为每 10000 人年 4 至 6 例。这项基于人群的研究报告 PHPT 的患病率为 0.84%。
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