Liver Institute Northwest, 3216 Northeast 45th Place Suite 212, Seattle, WA 98105, USA.
Department of Internal Medicine, UCSF Fresno, 155 North Fresno Street, Fresno, CA 93722, USA.
Clin Liver Dis. 2023 May;27(2):333-352. doi: 10.1016/j.cld.2023.01.006. Epub 2023 Mar 8.
The growing prevalence of nonalcoholic fatty liver disease (NAFLD) has sparked interest in understanding genetics and epigenetics associated with the development and progression of the disease. A better understanding of the genetic factors related to progression will be beneficial in the risk stratification of patients. These genetic markers can also serve as potential therapeutic targets in the future. In this review, we focus on the genetic markers associated with the progression and severity of NAFLD.
非酒精性脂肪性肝病（NAFLD）的患病率不断上升，促使人们关注与疾病发生和进展相关的遗传学和表观遗传学。更好地了解与进展相关的遗传因素将有助于对患者进行风险分层。这些遗传标志物也可能成为未来的潜在治疗靶点。在这篇综述中，我们重点介绍与 NAFLD 进展和严重程度相关的遗传标志物。
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