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立体定向放射外科在硬脑膜动静脉瘘治疗中的作用

Role of Stereotactic Radiosurgery in the Management of Dural AV Fistula.

作者信息

Garg Kanwaljeet, Agrawal Deepak

机构信息

Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.

出版信息

Neurol India. 2023 Mar-Apr;71(Supplement):S109-S114. doi: 10.4103/0028-3886.373634.

Abstract

Dural arteriovenous fistulas (DAVFs) are a relatively rare intracranial vascular malformation. The various treatment options for DAVFs include observation, compression therapy, endovascular therapy, radiosurgery, or surgery. A combination of these therapies may also be used. The treatment choice for DAVFs depends on the type of fistula, the severity of symptoms, DAVF angioarchitecture, and the efficacy and safety of treatments. The use of stereotactic radiosurgery (SRS) in DAVFs started in the late 1970s. There is a delay before the fistula gets obliterated after SRS and there is a risk of hemorrhage from the fistula till the fistula gets obliterated. Initial reports described the role of SRS in small DAVFs without severe symptoms, which were inaccessible by endovascular or surgical measures or in combination with embolization in larger DAVFs. SRS can be appropriate for indirect cavernous sinus DAVF fistulas (Barrow type B, C, and D). Borden types II and III and Cognard types IIb-V DAVFs have a high risk of hemorrhage and are traditionally considered less favorable to be treated with SRS as immediate treatment is required to decrease the risk of hemorrhage. However, recently SRS has been tried in these high-grade DAVF as a monotherapy. Factors that have a positive impact on the obliteration rates of DAVF following SRS are the location of DAVF with the cavernous sinus DAVF having much better obliteration rates than DAVF located at other locations, Borden Type I or Cognard Types III or IV DAVFs, absence of CVD, hemorrhage at the time of initial presentation, and target volume lesser than 1.5 mL.

摘要

硬脑膜动静脉瘘(DAVF)是一种相对罕见的颅内血管畸形。DAVF的各种治疗选择包括观察、压迫治疗、血管内治疗、放射外科治疗或手术治疗。也可联合使用这些治疗方法。DAVF的治疗选择取决于瘘的类型、症状的严重程度、DAVF血管构筑以及治疗的有效性和安全性。立体定向放射外科(SRS)在DAVF中的应用始于20世纪70年代末。SRS治疗后瘘口闭塞存在延迟,在瘘口闭塞之前存在瘘口出血的风险。最初的报告描述了SRS在无症状的小型DAVF中的作用,这些小型DAVF无法通过血管内或手术措施治疗,或在大型DAVF中与栓塞联合使用。SRS适用于间接海绵窦DAVF瘘(巴罗分型B、C和D)。博登II型和III型以及科尼亚尔IIb-V型DAVF有较高的出血风险,传统上认为不太适合用SRS治疗,因为需要立即治疗以降低出血风险。然而,最近SRS已被尝试用于这些高级别DAVF的单一治疗。对SRS后DAVF闭塞率有积极影响的因素包括DAVF位于海绵窦,其闭塞率比位于其他部位的DAVF好得多、博登I型或科尼亚尔III型或IV型DAVF、无心血管疾病、初次就诊时出血以及靶体积小于1.5 mL。

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