未经治疗的高血压会增加开角型青光眼的风险。

Increased Risks of Open-Angle Glaucoma in Untreated Hypertension.

机构信息

Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University, South Korea.

Department of Data Science, Sejong University, College of Software convergence, Seoul, Korea; Department of Precision MEdicine, Sungkyunkwan University College of Medicine, Seoul, Korea.

出版信息

Am J Ophthalmol. 2023 Aug;252:111-120. doi: 10.1016/j.ajo.2023.03.032. Epub 2023 Apr 7.

DOI:10.1016/j.ajo.2023.03.032

PMID:37030496

Abstract

PURPOSE

Hypertension (HTN) has been associated with open-angle glaucoma (OAG), but whether elevated blood pressure (BP) alone is associated with OAG is unknown. Whether stage 1 hypertension, as per the 2017 American College of Cardiology/American Heart Association (ACC/AHA) BP guidelines, increases the risk of the disease is uncertain.

DESIGN

Retrospective, observational, cohort study.

METHODS

A total of 360,330 subjects who were ≥40 years of age and not taking antihypertensive or antiglaucoma drugs at the time of health examinations between January 1, 2002, and December 31, 2003, were included. Subjects were categorized based on their untreated BP, into normal BP (systolic BP [SBP] <120 and diastolic BP [DBP] <80 mm Hg; n = 104,304), elevated BP (SBP 120-129 and DBP <80 mm Hg; n = 33,139), stage 1 HTN (SBP 130-139 or DBP 80-89 mm Hg; n = 122,534), or stage 2 HTN (SBP ≥140 or DBP ≥90mm Hg; n = 100,353). Cox regression analysis was performed to calculate hazard ratios (HR) of OAG risk.

RESULTS

The mean age of the subjects was 51.17 ± 8.97 years, and 56.2% were male. During a mean follow-up period of 11.76 ± 1.37 years, 12,841 subjects (3.56%) were diagnosed with OAG. Multivariable-adjusted HRs (95% CIs) were 1.056 (0.985-1.132) for elevated BP, 1.101(1.050-1.155) for stage 1 HTN, and 1.114(1.060-1.170) for stage 2 HTN with normal BP as the reference.

CONCLUSIONS

The risk for OAG becomes greater with increases in untreated BP. Stage 1 HTN per the 2017 ACC/AHA BP guidelines is a significant risk factor for OAG.

摘要

目的

高血压（HTN）与开角型青光眼（OAG）有关，但单纯血压升高是否与 OAG 有关尚不清楚。根据 2017 年美国心脏病学会/美国心脏协会（ACC/AHA）血压指南，1 期高血压是否会增加患病风险尚不确定。

设计

回顾性、观察性队列研究。

方法

共纳入 360330 名年龄≥40 岁且在 2002 年 1 月 1 日至 2003 年 12 月 31 日健康检查时未服用抗高血压或抗青光眼药物的受试者。根据未治疗的血压，将受试者分为正常血压（收缩压[SBP]＜120mmHg 和舒张压[DBP]＜80mmHg；n=104304）、血压升高（SBP120-129mmHg 和 DBP＜80mmHg；n=33139）、1 期高血压（SBP130-139mmHg 或 DBP80-89mmHg；n=122534）或 2 期高血压（SBP≥140mmHg 或 DBP≥90mmHg；n=100353）。采用 Cox 回归分析计算 OAG 风险的危险比（HR）。

结果

受试者的平均年龄为 51.17±8.97 岁，56.2%为男性。在平均 11.76±1.37 年的随访期间，有 12841 名受试者（3.56%）被诊断为 OAG。多变量调整后的 HR（95%CI）分别为血压升高（1.056，0.985-1.132）、1 期高血压（1.101，1.050-1.155）和 2 期高血压（1.114，1.060-1.170），以正常血压作为参考。