Zhang Wei, Diao Wei, Cheng Zhuzhong
Department of Nuclear Medicine, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, People's Republic of China.
Hell J Nucl Med. 2023 Jan-Apr;26(1):75-77. doi: 10.1967/s002449912559. Epub 2023 Apr 11.
Recently, radionuclide labelling fibroblast activating protein inhibitors (FAPI) is regarded as the most promising imaging tracer forvarious tumours. Here we present the imaging finding of aluminium-[F] fluoride (AlF)-labelled 1,4,7-triazacyclononane-N,N',N"-triacetic acid (AlF-NOTA-FAPI-04) and fluorine-18-fluorodeoxyglucose (F-FDG) in postoperative recurrence esophageal cancer. The results presented that imaging with AlF-NOTA-FAPI-04 showed significant improvement in detection of local recurrence and distant metastasis with higher maximum standardized uptake value (SUVmax) in the lesions compared with F-FDG.
最近，放射性核素标记的成纤维细胞激活蛋白抑制剂（FAPI）被认为是用于各种肿瘤的最有前景的成像示踪剂。在此，我们展示了铝-[F]氟化物（AlF）标记的1,4,7-三氮杂环壬烷-N,N',N''-三乙酸（AlF-NOTA-FAPI-04）和氟-18-氟脱氧葡萄糖（F-FDG）在术后复发性食管癌中的成像结果。结果表明，与F-FDG相比，AlF-NOTA-FAPI-04成像在检测局部复发和远处转移方面显示出显著改善，病变中的最大标准化摄取值（SUVmax）更高。
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