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心力衰竭与认知障碍:基于脑磁共振成像视角对神经影像学机制的叙述性综述

Heart failure and cognitive impairment: A narrative review of neuroimaging mechanism from the perspective of brain MRI.

作者信息

Li Tong, Bao Xiangyuan, Li Lin, Qin Rui, Li Cuicui, Wang Ximing

机构信息

Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.

School of Radiology, Shandong First Medical University, Taian, China.

出版信息

Front Neurosci. 2023 Mar 27;17:1148400. doi: 10.3389/fnins.2023.1148400. eCollection 2023.

Abstract

Both heart failure (HF) and cognitive impairment (CI) have a significant negative impact on the health of the elderly individuals. Magnetic resonance imaging (MRI) can non-invasively detect functional and structural variations in the heart and brain, making it easier to explore the connection between the heart and brain. According to neuroimaging studies, HF patients have a higher chance of developing CI because they have a variety of different types of brain injuries. To examine how HF and CI are influenced by one another, English-language literature was searched in the Web of Science, PubMed EMBASE (OVID), PsycInfo, and Scopus databases. The search terms included "high-frequency," "brain function," "brain injury," "cognition," "cognitive impairment," and "magnetic resonance imaging." Normal brain function is typically impaired by HF in the form of decreased cerebral perfusion pressure, inflammation, oxidative stress, and damage to the BBB, resulting in CI and subsequent HF. Early pathophysiological alterations in patients' brains have been widely detected using a range of novel MRI techniques, opening up new avenues for investigating the connection between HF and CI. This review aims to describe the pathogenesis of HF with CI and the early diagnostic role of MRI in the heart-brain domain.

摘要

心力衰竭(HF)和认知障碍(CI)均对老年人的健康产生重大负面影响。磁共振成像(MRI)能够非侵入性地检测心脏和大脑的功能及结构变化,从而更易于探究心脏与大脑之间的联系。根据神经影像学研究,HF患者发生CI的几率更高,因为他们存在多种不同类型的脑损伤。为了研究HF和CI如何相互影响,我们在科学网、PubMed EMBASE(OVID)、PsycInfo和Scopus数据库中检索了英文文献。检索词包括“高频”“脑功能”“脑损伤”“认知”“认知障碍”和“磁共振成像”。正常脑功能通常会因HF而以脑灌注压降低、炎症、氧化应激和血脑屏障受损的形式受到损害,进而导致CI及后续的HF。使用一系列新型MRI技术已广泛检测到患者大脑早期的病理生理改变,为研究HF与CI之间的联系开辟了新途径。本综述旨在描述合并CI的HF的发病机制以及MRI在心脏 - 脑领域的早期诊断作用。

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