Program of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, 739-8527, Higashi-Hiroshima, Japan.
Institute for Integrated Radiation and Nuclear Science, Kyoto University, Asashiro-Nishi, Kumatori-cho, 590-0494, Sennan-gun, Osaka, Japan.
Chembiochem. 2023 Aug 1;24(15):e202300186. doi: 10.1002/cbic.202300186. Epub 2023 Jul 4.
Minimally invasive boron neutron capture therapy (BNCT) is an elegant approach for cancer treatment. The highly selective and efficient deliverability of boron agents to cancer cells is the key to maximizing the therapeutic benefits of BNCT. In addition, enhancement of the frequencies to achieve boron neutron capture reaction is also significant in improving therapeutic efficacy by providing a highly concentrated boron agent in each boron nanoparticle. As the density of the thermal neutron beam remains low, it is unable to induce high-efficiency cell destruction. Herein, we report phospholipid-coated boronic oxide nanoparticles as agents for BNCT that can provide a highly concentrated boron atom in each nanoparticle. The current system exhibited in vitro BNCT activity seven times higher than that of commercial boron agents. Furthermore, the system could penetrate cancer spheroids deeply, efficiently suppressing thermal neutron irradiation-induced growth.
微创硼中子俘获治疗（BNCT）是一种治疗癌症的优雅方法。硼试剂对癌细胞的高度选择性和高效传递能力是最大限度发挥 BNCT 治疗益处的关键。此外，通过在每个硼纳米颗粒中提供高浓度的硼试剂，提高频率以实现硼中子俘获反应也可显著提高治疗效果。由于热中子束的密度仍然较低，因此无法诱导高效率的细胞破坏。在此，我们报告了磷脂包覆的氧化硼纳米颗粒作为 BNCT 试剂，其可在每个纳米颗粒中提供高浓度的硼原子。目前的系统在体外 BNCT 活性比商业硼试剂高 7 倍。此外，该系统可以深入穿透肿瘤球体，有效地抑制热中子辐照诱导的生长。
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