2020年至2021年期间，伊朗德黑兰塔莱加尼医院肝移植候选者中潜伏/慢性感染的患病率。
The prevalence of latent/chronic infection in liver transplant candidates in Taleghani Hospital of Tehran, Iran, from 2020 until 2021.
作者信息
Rabbani Amirhassan, Eghlimi Hesameddin, Khoshkbarforoushan Mina, Baziboroun Mana
机构信息
Department of General Surgery, Ayatollah Taleghani Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran.
Clinical Research of Development Unit of Rohani Hospital, Babol University of Medical Sciences, Babol, Iran.
出版信息
Gastroenterol Hepatol Bed Bench. 2023;16(1):478-485. doi: 10.22037/ghfbb.v16i1.2664.
AIM
The present study aimed to study the prevalence of various latent infections in pre-transplanted patients.
BACKGROUND
Due to chronic immunosuppressive therapy, patients receiving organ transplants are at risk for reactivation of various infections. Due to the complications in the course of diagnosing and treating the post-transplant infection, screening transplant recipients and donors is vital.
METHODS
This retrospective cohort study was performed between March 2020 and 2021. A total of 193 patients receiving a liver transplant in Taleghani Hospital, Tehran, Iran were enrolled.
RESULTS
One-hundred and three (53.4%) patients were men, with an average age of 48.4 ± 13.3 years. Among viruses, 177 (91.7%) patients had a positive IgG titer for CMV. Anti-EBV IgG was positive in 169 (87.6%) patients. One-hundred and seventy-five (90.7%) patients had a positive IgG titer for the VZV. One-hundred and sixty-six (86.0%) cases had positive IgG anti-HSV antibodies. According to our findings, none of the patients were infected with HIV, but 9 (4.7%) cases and 141 (73.1%) had positive anti-HCV and anti-HAV IgG antibodies, respectively. HBV surface (HBs) antigen was also reported positive in 17 (8.8%) patients, while the HBs antibody was positive in 29 (15.0%) patients.
CONCLUSION
In our study, most of the patients had positive serology for latent viral infections such as CMV, EBV, VZV, and HSV, but the prevalence of latent tuberculosis and viral hepatitis was low among transplant candidates.
目的
本研究旨在探讨移植前患者各种潜伏感染的患病率。
背景
由于长期免疫抑制治疗，接受器官移植的患者存在各种感染复发的风险。鉴于移植后感染诊断和治疗过程中的并发症，对移植受者和供者进行筛查至关重要。
方法
本回顾性队列研究于2020年3月至2021年进行。共纳入了伊朗德黑兰塔莱加尼医院193例接受肝移植的患者。
结果
103例（53.4%）患者为男性，平均年龄48.4±13.3岁。在病毒方面，177例（91.7%）患者CMV IgG滴度呈阳性。169例（87.6%）患者抗EBV IgG呈阳性。175例（90.7%）患者VZV IgG滴度呈阳性。166例（86.0%）病例抗HSV抗体呈阳性。根据我们的研究结果，所有患者均未感染HIV，但分别有9例（4.7%）和141例（73.1%）抗HCV和抗HAV IgG抗体呈阳性。17例（8.8%）患者乙肝表面（HBs）抗原也呈阳性，而29例（15.0%）患者HBs抗体呈阳性。
结论
在我们的研究中，大多数患者潜伏病毒感染如CMV、EBV、VZV和HSV的血清学检测呈阳性，但移植候选者中潜伏性结核和病毒性肝炎的患病率较低。
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