Department of Gastroenterology, Oita University, Oita, Japan.
Gastroenterological Disease Endoscopy Center, Takada Chuo Hospital, Oita, Japan.
Digestion. 2023;104(5):409-414. doi: 10.1159/000529648. Epub 2023 Apr 18.
Colon capsule endoscopy (CCE) is useful as an alternative examination for patients in whom colonoscopy is difficult. The Japanese Association for Capsule Endoscopy has published a recommended regimen for CCE using castor oil, which is becoming a standard examination method for CCE in Japan. However, castor oil has an unpleasant flavor. Therefore, patient acceptance is not good.
The aims were to develop a castor oil-filled capsule and evaluate its feasibility and patient acceptance in a retrospective, comparative study.
A dissolution study of pig-derived gelatin capsules filled with castor oil was performed using artificial gastric juice. The CCE excretion rates within battery lifetime, CCE examination times, endoscopic colonic cleansing levels, and patient acceptability between CCE boosters with a castor oil-filled capsule and without castor oil were retrospectively compared using medical information, clinical data, and endoscopic findings at Takada Chuo Hospital from September 2016 to August 2019.
The castor oil-filled capsules were completely disintegrated at approximately 1-3 min in artificial gastric juice. Bowel preparation with oil-filled capsules and without castor oil was performed in 27 and 24 patients, respectively. CCE excretion rates within battery life were 100% and 91.7% (p = 0.217), small bowel transit times were 115 min and 143 min (p = 0.046), colon transit times were 168 min and 148 min (p = 0.733), and adequate colonic cleansing rates were 85.2% and 86.3% (p = 1.000) in patients using bowel preparation with and without oil-filled capsules, respectively. Regarding acceptance, the taste was not problematic in 85.2%, and tolerability for the next CCE was 96.3%.
CCE using a castor oil-filled capsule method achieved high examination performance and sufficient patient tolerability.
结肠胶囊内镜（CCE）是一种替代结肠镜检查的方法，适用于结肠镜检查困难的患者。日本胶囊内镜协会已经发布了使用蓖麻油进行 CCE 的推荐方案，这在日本已成为 CCE 的标准检查方法。然而，蓖麻油味道难闻。因此，患者接受度不佳。
旨在开发一种充满蓖麻油的胶囊，并在回顾性比较研究中评估其可行性和患者接受度。
使用人工胃液对填充有蓖麻油的猪源明胶胶囊进行溶解研究。2016 年 9 月至 2019 年 8 月，回顾性比较我院使用和不使用充满蓖麻油的胶囊的 CCE 排泄率、电池寿命内的 CCE 检查时间、内镜结肠清洁度以及患者接受度。
充满蓖麻油的胶囊在人工胃液中约 1-3 分钟内完全崩解。油胶囊和无蓖麻油的肠道准备分别在 27 名和 24 名患者中进行。电池寿命内的 CCE 排泄率分别为 100%和 91.7%（p=0.217），小肠转运时间分别为 115 分钟和 143 分钟（p=0.046），结肠转运时间分别为 168 分钟和 148 分钟（p=0.733），使用和不使用充满蓖麻油的胶囊进行肠道准备的患者的结肠清洁度分别为 85.2%和 86.3%（p=1.000）。在接受度方面，85.2%的患者认为味道没有问题，96.3%的患者表示愿意接受下一次 CCE。
使用充满蓖麻油的胶囊方法的 CCE 检查性能高，患者耐受性好。
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