Donahue P E, Samelson S, Schlesinger P K, Bombeck C T, Nyhus L M
Ann Surg. 1986 May;203(5):505-11. doi: 10.1097/00000658-198605000-00009.
During a 15-year period, 62 patients were treated for achalasia of the esophagus. Pneumatic dilation (PD) had been performed initially in 46 and was successful in 23; failures were due to acute perforation of the esophagus, persistent dysphagia, or pathologic gastroesophageal reflux. Esophagomyotomy alone (EM) was performed in 19 individuals resulting in definite improvement in 12; four patients had moderate reflux or dysphagia, and three of these required another surgical procedure. An extended myotomy with an antireflux procedure (M-NF) was performed in 13 patients with symptomatic relief in 12; one patient required reconstruction of a too-tight fundoplication that caused persistent dysphagia. The advantages of pneumatic dilation were the ease of performance, patient acceptability, and an overall efficacy of 50%. Definitive surgical therapy, while more predictably effective in relieving dysphagia, was considerably more expensive in terms of patient discomfort and time. When pathologic reflux was present following a previous procedure, the M-NF was performed; obstruction of the esophagus did not occur if the fundoplication was "floppy." The M-NF deserves consideration as the surgical procedure of choice for achalasia.
在15年期间,62例患者接受了食管贲门失弛缓症的治疗。最初对46例患者进行了气囊扩张术(PD),其中23例成功;失败原因包括食管急性穿孔、持续性吞咽困难或病理性胃食管反流。19例患者仅接受了食管肌层切开术(EM),其中12例有明确改善;4例患者有中度反流或吞咽困难,其中3例需要再次手术。对13例患者进行了扩大肌层切开术加抗反流手术(M-NF),12例症状缓解;1例患者需要重建过紧的胃底折叠术,该手术导致持续性吞咽困难。气囊扩张术的优点是操作简便、患者可接受性好,总体有效率为50%。确定性手术治疗虽然在缓解吞咽困难方面更具可预测性,但在患者不适和时间方面成本要高得多。如果先前手术后出现病理性反流,则进行M-NF;如果胃底折叠术“松弛”,则不会发生食管梗阻。M-NF值得作为贲门失弛缓症的首选手术方法加以考虑。