Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care, Beijing, China; Clinical Trial Institution Office, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care, Beijing, China.
Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care, Beijing, China; University Women's Hospital and Research Centre for Women's Health, Department of Women's Health, University of Tuebingen, Tuebingen, Germany.
Maturitas. 2023 Jun;172:15-22. doi: 10.1016/j.maturitas.2023.04.002. Epub 2023 Apr 18.
The aim of this study was to investigate the factors affecting the sex lives of postmenopausal Chinese women, especially the influence of body weight, climacteric symptoms and androgens.
A total of 437 postmenopausal women were investigated in the Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University and two allied medical institutions from April 2020 to March 2021. Sociodemographic data were collected. Female sexual dysfunction was evaluated using the Female Sexual Function Index (FSFI). The modified Kupperman index was used to assess climacteric symptoms. Methods based on liquid chromatography-tandem mass spectrometry were employed to measure the serum levels of total testosterone, bioavailable testosterone, free testosterone, androstenedione and dehydroepiandrosterone. Pearson's correlation coefficient and multiple linear regression analyses were performed to determine the correlation between characteristics and FSFI scores.
The multivariate linear regression analysis revealed that the modified Kupperman index score and the factor unsatisfactory marital relations had the strongest negative correlations with all FSFI domains (P < 0.05); secondary education level was negatively associated with desire, arousal and orgasm (P < 0.05). Total testosterone positively affected the score for pain (P < 0.05). There was no correlation between bioavailable testosterone, free testosterone, androstenedione and dehydroepiandrosterone and all FSFI domains (P > 0.05).
Climacteric symptoms and sociodemographic factors had a notable effect on sexual function. It is necessary to provide more attention to and intervention for their climacteric symptoms to improve the quality of life of postmenopausal women.
本研究旨在探讨影响中国绝经后女性性生活的因素，尤其是体重、更年期症状和雄激素的影响。
2020 年 4 月至 2021 年 3 月，我们在北京妇产医院妇科内分泌科和两家合作医疗机构对 437 名绝经后妇女进行了调查。收集社会人口学资料。采用女性性功能指数（FSFI）评估女性性功能障碍。采用改良 Kupperman 指数评估更年期症状。采用液相色谱-串联质谱法测定总睾酮、生物可利用睾酮、游离睾酮、雄烯二酮和脱氢表雄酮水平。采用 Pearson 相关系数和多元线性回归分析确定特征与 FSFI 评分之间的相关性。
多元线性回归分析显示，改良 Kupperman 指数评分和不满意婚姻关系因素与所有 FSFI 领域呈最强负相关（P<0.05）；中学教育程度与性欲、唤醒和性高潮呈负相关（P<0.05）。总睾酮对疼痛评分有积极影响（P<0.05）。生物可利用睾酮、游离睾酮、雄烯二酮和脱氢表雄酮与所有 FSFI 领域均无相关性（P>0.05）。
更年期症状和社会人口学因素对性功能有显著影响。有必要对其更年期症状给予更多关注和干预，以提高绝经后妇女的生活质量。
