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本文引用的文献

1
Scientific Opinion on Flavouring Group Evaluation 217 Revision 2 (FGE.217Rev2), consideration of genotoxic potential for α,β-unsaturated ketones and precursors from chemical subgroup 4.1 of FGE.19: lactones.关于调味剂组评估217修订版2（FGE.217Rev2）的科学意见，对FGE.19化学亚组4.1中的α,β-不饱和酮及其前体（内酯）的遗传毒性潜力的考量
EFSA J. 2019 Jan 25;17(1):e05568. doi: 10.2903/j.efsa.2019.5568. eCollection 2019 Jan.

调味剂组评估217修订版3（FGE.217Rev3）：对FGE.19化学亚组4.1（内酯）中的α,β-不饱和酮及其前体的遗传毒性潜力的考量。

Flavouring Group Evaluation 217 Revision 3 (FGE.217Rev3): consideration of genotoxic potential for α,β-unsaturated ketones and precursors from chemical subgroup 4.1 of FGE.19: lactones.

作者信息

Younes Maged, Aquilina Gabriele, Castle Laurence, Degen Gisela, Engel Karl-Heinz, Fowler Paul J, Frutos Fernandez Maria José, Fürst Peter, Gundert-Remy Ursula, Gürtler Rainer, Husøy Trine, Manco Melania, Moldeus Peter, Passamonti Sabina, Shah Romina, Waalkens-Berendsen Ine, Wright Matthew, Benigni Romualdo, Bolognesi Claudia, Chipman Kevin, Cordelli Eugenia, Carfì Maria, Mennes Wim

出版信息

EFSA J. 2023 Apr 20;21(4):e07967. doi: 10.2903/j.efsa.2023.7967. eCollection 2023 Apr.

DOI:10.2903/j.efsa.2023.7967
PMID:37089172
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10117171/
Abstract

The Panel on Food Additives and Flavourings of the European Food Safety Authority was requested to evaluate the genotoxic potential of four flavouring substances [FL-no: 10.023, 10.030, 10.057 and 13.012] from subgroup 4.1 of FGE.19. For three of these substances [FL-no: 10.023, 10.030 and 13.012], the concern for genotoxicity has been ruled out in previous revisions of Flavouring Group Evaluation 217 (FGE.217). However, in FGE.217Rev2, a concern for genotoxicity could not be ruled out for 3a,4,5,7a-tetrahydro-3,6-dimethylbenzofuran-2(3)-one [FL-no: 10.057]. After publication of FGE.217Rev2, industry provided additional genotoxicity studies for [FL-no: 10.057], which are evaluated in the present opinion FGE.217Rev3. The flavouring substance [FL-no: 10.057] did not induce gene mutations or numerical or structural chromosomal aberrations . Based on these data, the Panel concluded that the concern for genotoxicity is ruled out for [FL-no: 10.057]. Consequently, it can be evaluated through the Procedure.

摘要

应要求，欧洲食品安全局食品添加剂和调味剂小组对FGE.19第4.1亚组中的四种调味物质[FL编号：10.023、10.030、10.057和13.012]的遗传毒性潜力进行评估。对于其中三种物质[FL编号：10.023、10.030和13.012]，在调味剂组评估217（FGE.217）的先前修订版中已排除对其遗传毒性的担忧。然而，在FGE.217Rev2中，对于3a,4,5,7a-四氢-3,6-二甲基苯并呋喃-2(3)-酮[FL编号：10.057]，无法排除对其遗传毒性的担忧。在FGE.217Rev2发布后，业界为[FL编号：10.057]提供了额外的遗传毒性研究，本意见FGE.217Rev3对这些研究进行了评估。调味物质[FL编号：10.057]未诱导基因突变或染色体数目或结构畸变。基于这些数据，小组得出结论，排除对[FL编号：10.057]遗传毒性的担忧。因此，可以通过该程序对其进行评估。