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CD147 在肝细胞癌发生发展及诊断中的作用。

Role of CD147 in the development and diagnosis of hepatocellular carcinoma.

机构信息

Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.

Department of Cardiothoracic Surgery, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.

出版信息

Front Immunol. 2023 Apr 6;14:1149931. doi: 10.3389/fimmu.2023.1149931. eCollection 2023.

DOI:10.3389/fimmu.2023.1149931
PMID:37090718
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10115957/
Abstract

Hepatocellular carcinoma (HCC) is the most common primary liver cancer, and the third leading cause of cancer-related deaths worldwide. HCC is characterized by insidious onset, and most patients are diagnosed at an advanced stage with a poor prognosis. Identification of biomarkers for HCC onset and progression is imperative to development of effective diagnostic and therapeutic strategies. CD147 is a glycoprotein that is involved in tumor cell invasion, metastasis and angiogenesis through multiple mechanisms. In this review, we describe the molecular structure of CD147 and its role in regulating HCC invasion, metastasis and angiogenesis. We highlight its potential as a diagnostic and therapeutic target for HCC.

摘要

肝细胞癌（HCC）是最常见的原发性肝癌，也是全球癌症相关死亡的第三大主要原因。HCC 的特点是隐匿性发病，大多数患者在晚期被诊断，预后不良。确定 HCC 发病和进展的生物标志物对于开发有效的诊断和治疗策略至关重要。CD147 是一种糖蛋白，通过多种机制参与肿瘤细胞的侵袭、转移和血管生成。在这篇综述中，我们描述了 CD147 的分子结构及其在调节 HCC 侵袭、转移和血管生成中的作用。我们强调了它作为 HCC 诊断和治疗靶点的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85be/10115957/8e571d5cb5dd/fimmu-14-1149931-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85be/10115957/150451297e2d/fimmu-14-1149931-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85be/10115957/86fc364e6629/fimmu-14-1149931-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85be/10115957/8e571d5cb5dd/fimmu-14-1149931-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85be/10115957/150451297e2d/fimmu-14-1149931-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85be/10115957/86fc364e6629/fimmu-14-1149931-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85be/10115957/8e571d5cb5dd/fimmu-14-1149931-g003.jpg

相似文献

[1]
Role of CD147 in the development and diagnosis of hepatocellular carcinoma.

Front Immunol. 2023

[2]
Hypo-phosphorylated CD147 promotes migration and invasion of hepatocellular carcinoma cells and predicts a poor prognosis.

Cell Oncol (Dordr). 2019-4-23

[3]
Circulating CD147 predicts mortality in advanced hepatocellular carcinoma.

J Gastroenterol Hepatol. 2016-2

[4]
Promoter hypomethylation up-regulates CD147 expression through increasing Sp1 binding and associates with poor prognosis in human hepatocellular carcinoma.

J Cell Mol Med. 2010-7-12

[5]
Full-length soluble CD147 promotes MMP-2 expression and is a potential serological marker in detection of hepatocellular carcinoma.

J Transl Med. 2014-7-4

[6]
A novel small-molecule compound targeting CD147 inhibits the motility and invasion of hepatocellular carcinoma cells.

Oncotarget. 2016-2-23

[7]
HAb18G/CD147 functions in invasion and metastasis of hepatocellular carcinoma.

Mol Cancer Res. 2007-6

[8]
Circular RNAs in hepatocellular carcinoma: Biomarkers, functions and mechanisms.

Life Sci. 2019-7-15

[9]
Regulation of a TGF-β1-CD147 self-sustaining network in the differentiation plasticity of hepatocellular carcinoma cells.

Oncogene. 2016-4-4

[10]
CD147/EMMPRIN: an effective therapeutic target for hepatocellular carcinoma.

J Drug Target. 2013-4

引用本文的文献

[1]
Serum EMMPRIN/CD147 promotes the lung pre-metastatic niche in a D2A1 mammary carcinoma mouse model.

Front Immunol. 2025-4-30

[2]
Serum-biomarker-based population screening model for hepatocellular carcinoma.

iScience. 2025-2-8

[3]
An Anti-CD147 Antibody-Drug Conjugate Mehozumab-DM1 is Efficacious Against Hepatocellular Carcinoma in Cynomolgus Monkey.

Adv Sci (Weinh). 2025-4

[4]
Hitting the target: cell signaling pathways modulation by extracellular vesicles.

Extracell Vesicles Circ Nucl Acids. 2024-9-24

[5]
Targeting autophagy in HCC treatment: exploiting the CD147 internalization pathway.

Cell Commun Signal. 2024-12-3

[6]
Relationships between tumor CD147 expression, tumor-infiltrating lymphocytes, and oncostatin M in hepatocellular carcinoma.

Virchows Arch. 2024-10-12

[7]
Hydrogen Sulfide Modulation of Matrix Metalloproteinases and CD147/EMMPRIN: Mechanistic Pathways and Impact on Atherosclerosis Progression.

Biomedicines. 2024-8-26

[8]
Regulatory T cells and immune escape in HCC: understanding the tumor microenvironment and advancing CAR-T cell therapy.

Front Immunol. 2024

[9]
TIE1 promotes cervical cancer progression via Basigin-matrix metalloproteinase axis.

Int J Biol Sci. 2024-4-8

[10]
Chimeric Antigen Receptor T Cell Therapy for Hepatocellular Carcinoma: Where Do We Stand?

Int J Mol Sci. 2024-2-23

本文引用的文献

[1]
Calycosin inhibits breast cancer cell migration and invasion by suppressing EMT via BATF/TGF-β1.

Aging (Albany NY). 2021-6-7

[2]
The Ok blood group system: an update.

Immunohematology. 2021-3

[3]
CD147 regulates antitumor CD8 T-cell responses to facilitate tumor-immune escape.

Cell Mol Immunol. 2021-8

[4]
Pseudolaric Acid B Inhibits Proliferation, Invasion, and Angiogenesis in Esophageal Squamous Cell Carcinoma Through Regulating CD147.

Drug Des Devel Ther. 2020

[5]
Investigation of physicochemical, nutritional, and sensory qualities of muffins incorporated with dried brewer's spent grain flours as a source of dietary fiber and protein.

J Food Sci. 2020-11

[6]
Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma.

Nat Commun. 2020-9-23

[7]
CD147 promotes DNA damage response and gemcitabine resistance via targeting ATM/ATR/p53 and affects prognosis in pancreatic cancer.

Biochem Biophys Res Commun. 2020-7-12

[8]
CD206 tumor-associated macrophages promote proliferation and invasion in oral squamous cell carcinoma via EGF production.

Sci Rep. 2019-10-10

[9]
Identification of ADAM12 as a Novel Basigin Sheddase.

Int J Mol Sci. 2019-4-22

[10]
Deletion of BSG1 in Chlamydomonas reinhardtii leads to abnormal starch granule size and morphology.

Sci Rep. 2019-2-13

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