[十二指肠型滤泡性淋巴瘤的临床研究进展——综述]

[Clinical Research Advances of Duodenal-Type Follicular Lymphoma--Review].

作者信息

Li Hong-Yi, Zhang Jun-Dong, Lu Xue-Chun

机构信息

Medical School of Chinese PLA; Department of Hematology, The Second Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Geriatric Disease, Beijing 100853, China.

Medical School of Chinese PLA; Department of Hematology, The Second Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Geriatric Disease, Beijing 100853, China .E-mail:

出版信息

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2023 Apr;31(2):581-584. doi: 10.19746/j.cnki.issn.1009-2137.2023.02.039.

DOI:10.19746/j.cnki.issn.1009-2137.2023.02.039

PMID:37096537

Abstract

Duodenal-type follicular lymphoma (DFL) is a unique subtype of follicular lymphoma (FL), which often involves the second portion of duodenum (descending part of duodenum). Due to its speciﬁc pathological features, such as lack of follicular dendritic cells meshwork and disappearance of activation-induced cytidine deaminase expression, DFL presents an inert clinical course and is often confined to the intestinal tract. Inflammation-related biomarkers suggest that the microenvironment may play a likely role in the pathogenesis and favorable prognosis of DFL. Since patients generally have no obvious clinical symptoms and low progression rate, the treatment regimen for DFL is mainly observation and waiting (W&W) strategy. This study will review the latest research progress of epidemiology, diagnosis, treatment and prognosis of DFL in recent years.

摘要

十二指肠型滤泡性淋巴瘤（DFL）是滤泡性淋巴瘤（FL）的一种独特亚型，常累及十二指肠第二部（十二指肠降部）。由于其特定的病理特征，如缺乏滤泡树突状细胞网状结构以及活化诱导胞苷脱氨酶表达消失，DFL呈现惰性临床病程，且常局限于肠道。炎症相关生物标志物表明，微环境可能在DFL的发病机制及良好预后中发挥作用。由于患者通常无明显临床症状且进展率低，DFL的治疗方案主要是观察等待（W&W）策略。本研究将综述近年来DFL在流行病学、诊断、治疗及预后方面的最新研究进展。