College of Marine Sciences, South China Agricultural University, Guangzhou 510641, China; Guangdong Provincial Key Laboratory of Utilization and Conservation of Food and Medicinal Resources in Northern Region, Shaoguan University, Shaoguan 512005, China.
College of Agriculture, College of Tobacco Science, Guizhou University, Guiyang 550025, China.
Sci Total Environ. 2023 Jul 15;882:163679. doi: 10.1016/j.scitotenv.2023.163679. Epub 2023 Apr 24.
Microplastics (1 μm - 5 mm) and nanoplastics (1-100 nm), commonly referred to as micro(nano)plastics (MNPs), are widespread in both freshwater and marine habitats, and they can have significant negative effects on exposed organisms. In recent years, the transgenerational toxicity of MNPs has gained considerable attention owing to its potential to harm both parents and descendants. This review summarizes the available literature on the transgenerational combined effects of MNPs and chemicals, aimed at providing a deeper understanding of the toxicity of MNPs and co-occurring chemicals to both parents and offspring in the aquatic environment. The reviewed studies showed that exposure to MNPs, along with inorganic and organic pollutants, increased bioaccumulation of both MNPs and co-occurring chemicals and significantly impacted survival, growth, and reproduction, as well as induced genetic toxicity, thyroid disruption, and oxidative stress. This study further highlights the factors affecting the transgenerational toxicity of MNPs and chemicals, such as MNP characteristics (polymer type, shape, size, concentration, and aging), type of exposure and duration, and interactions with other chemicals. Finally, future research directions, such as the careful consideration of MNP properties in realistic environmental conditions, the use of a broader range of animal models, and the examination of chronic exposure and MNP-chemical mixture exposure, are also discussed as a means of broadening our understanding of the effects of MNPs that are passed down from generation to generation.
微塑料（1μm-5mm）和纳米塑料（1-100nm），通常被称为微（纳）塑料（MNPs），广泛存在于淡水和海洋生境中，它们会对暴露的生物产生重大的负面影响。近年来，由于 MNPs 可能对父母和后代造成伤害，其跨代毒性引起了相当大的关注。本综述总结了关于 MNPs 和化学物质联合的跨代毒性的现有文献，旨在更深入地了解 MNPs 和共存化学物质对水生环境中父母和后代的毒性。综述研究表明，暴露于 MNPs 以及无机和有机污染物会增加 MNPs 和共存化学物质的生物累积，并显著影响生存、生长和繁殖，以及诱导遗传毒性、甲状腺紊乱和氧化应激。本研究进一步强调了影响 MNPs 和化学物质跨代毒性的因素，如 MNP 特性（聚合物类型、形状、尺寸、浓度和老化）、暴露类型和持续时间，以及与其他化学物质的相互作用。最后，还讨论了未来的研究方向，例如在实际环境条件下仔细考虑 MNP 特性、使用更广泛的动物模型以及检查慢性暴露和 MNP-化学混合物暴露，以拓宽我们对 MNPs 代际传递影响的理解。
