Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai, 201321, China.
Shanghai Key Laboratory of Radiation Oncology (20dz2261000), Shanghai, 201321, China.
Eur Arch Otorhinolaryngol. 2023 Aug;280(8):3835-3841. doi: 10.1007/s00405-023-07963-5. Epub 2023 Apr 26.
To analyze the risk factors for synchronous lung metastases (LM) in patients with major salivary gland mucoepidermoid carcinoma (MaSG-MEC).
MaSG-MEC patients were extracted from the Surveillance, Epidemiology and End Results (SEER) database between 2010 and 2014. Descriptive statistics were used to examine the baseline characteristics of the patients. We examined the association between risk factors and synchronous LM using Chi-squared tests. The primary study outcomes were overall survival (OS) and cancer-specific survival (CSS). Kaplan-Meier survival curves were compared using the log-rank test. Hazard analysis was conducted using the Cox proportional hazards model.
A total of 701 patients were analyzed, which including 8 patients (1.1%) with synchronous LM, and 693 patients without synchronous LM (98.9%). Lower T or N classification, and highly differentiated disease were associated with a significantly lower risk of LM and multivariate logistic regression analysis showed that lower T classification were associated with a significantly lower risk of LM (P < 0.05, respectively). Elderly Caucasian male patients with poorly differentiated disease, multiple sites of metastases and no surgical therapy to primary tumor were more likely to reduce life expectancy.
By analyzing data from a large cohort, lower T or N classification and highly differentiated disease were associated with a significantly lower risk of LM. Elderly Caucasian male patients with poorly differentiated disease, multiple sites of metastases and no surgical therapy to primary tumor were more likely to reduce life expectancy. More accurate assessments of LM will be imperative for early diagnosis and treatment in patients who harbored with higher T or N classification and poorly differentiated disease.
分析大涎腺黏液表皮样癌（MaSG-MEC）患者同步肺转移（LM）的危险因素。
从 2010 年至 2014 年，从监测、流行病学和最终结果（SEER）数据库中提取 MaSG-MEC 患者。使用描述性统计分析患者的基线特征。我们使用卡方检验来检查危险因素与同步 LM 之间的关联。主要研究结果是总生存期（OS）和癌症特异性生存期（CSS）。使用对数秩检验比较 Kaplan-Meier 生存曲线。使用 Cox 比例风险模型进行风险分析。
共分析了 701 例患者，其中 8 例（1.1%）为同步 LM，693 例无同步 LM（98.9%）。较低的 T 或 N 分类和高度分化的疾病与 LM 风险显著降低相关，多因素逻辑回归分析显示，较低的 T 分类与 LM 风险显著降低相关（P<0.05）。分化差、多处转移且原发肿瘤无手术治疗的老年白种男性患者更有可能降低预期寿命。
通过分析大样本队列的数据，较低的 T 或 N 分类和高度分化的疾病与 LM 风险显著降低相关。分化差、多处转移且原发肿瘤无手术治疗的老年白种男性患者更有可能降低预期寿命。对于 T 或 N 分类较高和分化较差的患者，更准确地评估 LM 将对早期诊断和治疗至关重要。
