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大豆卵磷脂和牛脑脑苷脂对健康雄性 Wistar 大鼠的作用测定及比较。

Determination and Comparison of Soybean Lecithin and Bovine Brain Plasmalogens Effects in Healthy Male Wistar Rats.

机构信息

Federal State Budgetary Scientific Institution "Federal Research Centre of Nutrition, Biotechnology and Food Safety", Ustyinsky Proezd, 2/14, 109240 Moscow, Russia.

出版信息

Int J Mol Sci. 2023 Apr 21;24(8):7643. doi: 10.3390/ijms24087643.

Abstract

The aim of this study was to investigate the effects of soybean lecithin and plasmalogens concentrating on a variety of physiological tests and biochemical analyses in healthy Wistar rats. For six weeks, male Wistar rats were given a standard diet that included plasmalogens or soybean lecithin. We measured anxiety levels, overall exploratory activity, short- and long-term memory, cognitive abilities, and grip strength. Lecithin increased significantly anxiety and enhanced memory and cognitive functions. Plasmalogens significantly improved appetite and increased grip strength. When compared to plasmalogens, lecithin significantly raised HDL levels while lowering LDL levels. The plasmalogens group showed a significant increase in the C16:0DMA/C16:0 ratio, which led us to assume that plasmalogen consumption could increase their synthesis in neural tissue. The study's findings imply that, despite their various modes of action, soy lecithin and plasmalogens may both be significant nutritional components for enhancing cognitive functions.

摘要

本研究旨在探讨大豆卵磷脂和神经节苷脂集中对健康 Wistar 大鼠各种生理测试和生化分析的影响。六周内,雄性 Wistar 大鼠给予包含神经节苷脂或大豆卵磷脂的标准饮食。我们测量了焦虑水平、整体探索活动、短期和长期记忆、认知能力和握力。卵磷脂显著增加了焦虑,增强了记忆和认知功能。神经节苷脂显著改善了食欲,增加了握力。与神经节苷脂相比,卵磷脂显著提高了高密度脂蛋白水平,同时降低了低密度脂蛋白水平。神经节苷脂组 C16:0DMA/C16:0 比值显著增加,这使我们假设神经节苷脂的消耗可能会增加其在神经组织中的合成。该研究结果表明,尽管大豆卵磷脂和神经节苷脂的作用方式不同,但它们都可能是增强认知功能的重要营养成分。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbce/10145545/dc6aba028057/ijms-24-07643-g001.jpg

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