Maison Zabal, 64470 Etchebar, France.
Independent Researcher, Flora Bellini, Uxbridge, UK.
Viruses. 2023 Mar 23;15(4):818. doi: 10.3390/v15040818.
After an incubation period of weeks to months, up to 14% of cats infected with feline coronavirus (FCoV) develop feline infectious peritonitis (FIP): a potentially lethal pyogranulomatous perivasculitis. The aim of this study was to find out if stopping FCoV faecal shedding with antivirals prevents FIP. Guardians of cats from which FCoV had been eliminated at least 6 months earlier were contacted to find out the outcome of their cats; 27 households were identified containing 147 cats. Thirteen cats were treated for FIP, 109 cats shed FCoV and 25 did not; a 4-7-day course of oral GS-441524 antiviral stopped faecal FCoV shedding. Follow-up was from 6 months to 3.5 years; 11 of 147 cats died, but none developed FIP. A previous field study of 820 FCoV-exposed cats was used as a retrospective control group; 37 of 820 cats developed FIP. The difference was statistically highly significant ( = 0.0062). Cats from eight households recovered from chronic FCoV enteropathy. Conclusions: the early treatment of FCoV-infected cats with oral antivirals prevented FIP. Nevertheless, should FCoV be re-introduced into a household, then FIP can result. Further work is required to establish the role of FCoV in the aetiology of feline inflammatory bowel disease.
在感染猫冠状病毒（FCoV）后的数周到数月潜伏期内，多达 14%的猫会发展为猫传染性腹膜炎（FIP）：一种潜在致命的化脓性血管周炎。本研究旨在确定使用抗病毒药物阻止 FCoV 粪便脱落是否能预防 FIP。联系了至少 6 个月前已从 FCoV 中消除的猫的主人，以了解他们的猫的结果；确定了 27 个包含 147 只猫的家庭。13 只猫因 FIP 接受治疗，109 只猫排出 FCoV，25 只猫未排出；为期 4-7 天的口服 GS-441524 抗病毒治疗可阻止粪便 FCoV 脱落。随访时间为 6 个月至 3.5 年；147 只猫中有 11 只死亡，但没有发展为 FIP。之前对 820 只暴露于 FCoV 的猫进行的一项现场研究被用作回顾性对照组；820 只猫中有 37 只发展为 FIP。差异具有统计学显著意义（=0.0062）。来自 8 个家庭的猫从慢性 FCoV 肠炎中康复。结论：用口服抗病毒药物早期治疗感染 FCoV 的猫可预防 FIP。然而，如果 FCoV 再次引入家庭，那么可能会导致 FIP。需要进一步研究以确定 FCoV 在猫炎症性肠病病因学中的作用。
