葡萄球菌生物膜：万古霉素联合或不联合利福平的穿透性和生物利用度。
Staphylococcal biofilm: penetration and bioavailability of vancomycin with or without rifampin.
机构信息
Infectious Diseases Research Program, Providence Veterans Affairs Medical Center, Providence, RI, USA.
Infectious Diseases Research Program, Providence Veterans Affairs Medical Center, Providence, RI, USA; College of Pharmacy, University of Rhode Island, Kingston, RI, USA.
出版信息
Diagn Microbiol Infect Dis. 2023 Jul;106(3):115947. doi: 10.1016/j.diagmicrobio.2023.115947. Epub 2023 Mar 29.
We measured antibiotic penetration and bioavailability in staphylococcus biofilms using simulated humanized concentrations of fluorescent vancomycin plus or minus rifampin. Vancomycin percent recovery across biofilm layers was:upper = 46%, middle = 40%, and lower = 33%. Vancomycin plus rifampin was not significantly different (P = 0.65). Addition of rifampin did not improve vancomycin penetration across biofilm layers.
我们使用模拟的人性化荧光万古霉素浓度加或不加利福平来测量金黄色葡萄球菌生物膜中的抗生素渗透和生物利用度。万古霉素在生物膜各层的回收率分别为：上层=46%，中层=40%，下层=33%。万古霉素加利福平无显著差异（P=0.65）。加用利福平并不能改善万古霉素在生物膜各层的渗透。
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