Kobilka Institute of Innovative Drug Discovery, Shenzhen Key Laboratory of Steroid Drug Discovery and Development, School of Medicine, The Chinese University of Hong Kong, 518172, Shenzhen, Guangdong, China.
School of Medicine, Tsinghua University, 100084, Beijing, China.
Signal Transduct Target Ther. 2023 May 3;8(1):177. doi: 10.1038/s41392-023-01427-2.
Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors. Identifying treatment targets is challenging because the diseases are resulting from heterogeneous biological, genetic, and environmental factors. Nevertheless, the increasing understanding of G protein-coupled receptor (GPCR) opens a new possibility in drug discovery. Harnessing our knowledge of molecular mechanisms and structural information of GPCRs will be advantageous for developing effective drugs. This review provides an overview of the role of GPCRs in various neurodegenerative and psychiatric diseases. Besides, we highlight the emerging opportunities of novel GPCR targets and address recent progress in GPCR drug development.
神经精神疾病是一种多因素疾病，具有多种病因。由于这些疾病是由异质的生物、遗传和环境因素共同导致的，因此确定治疗靶点具有挑战性。然而，人们对 G 蛋白偶联受体（GPCR）的认识不断加深，为药物发现开辟了新的可能性。利用我们对 GPCR 分子机制和结构信息的了解，将有利于开发有效的药物。本文综述了 GPCR 在各种神经退行性和精神疾病中的作用。此外，我们还强调了新型 GPCR 靶点的出现机会，并介绍了 GPCR 药物开发的最新进展。
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