Pharma Technical Development, F. Hoffmann-La Roche Ltd., Grenzacher Str. 124, CH-4070 Basel, Switzerland; Center of Drug Absorption and Transport, Department of Biopharmaceutics and Pharmaceutical Technology, Institute of Pharmacy, University of Greifswald, Felix-Hausdorff-Str. 3, 17489 Greifswald, Germany.
Center of Drug Absorption and Transport, Department of Biopharmaceutics and Pharmaceutical Technology, Institute of Pharmacy, University of Greifswald, Felix-Hausdorff-Str. 3, 17489 Greifswald, Germany.
Eur J Pharm Sci. 2023 Aug 1;187:106453. doi: 10.1016/j.ejps.2023.106453. Epub 2023 May 4.
Older adults are the main users of medicine and due to common multimorbidity they are often confronted with a complex medication management. This review article provides a brief overview on aspects of medication management, i.e., maintaining a stock of the required medicine, understanding and following the instructions for use, coping with the primary and secondary packaging, as well as the preparation prior to use. However, the main focus is on the drug intake itself and the review provides an overview of the current understanding of real life dosing conditions in older adults and geriatric patients. It elaborates the acceptability of dosage forms, in particular solid oral dosage forms as they represent the majority of dosage forms taken by this patient population. An improved understanding of the needs of older adults and geriatric patients, their acceptability of various dosage forms, and the circumstances under which they manage their medications will allow for the design of more patient-centric drug products.
老年人是医学的主要使用者,由于常见的多种疾病,他们经常面临复杂的药物管理。本文综述简要概述了药物管理的各个方面,例如,保持所需药物的库存,理解和遵循使用说明,处理主要和次要包装,以及使用前的准备。然而,主要重点是药物摄入本身,综述提供了对老年人和老年患者实际生活中用药条件的当前理解的概述。它阐述了剂型的可接受性,特别是固体制剂,因为它们代表了这一患者群体所使用的大多数剂型。更好地了解老年人和老年患者的需求、他们对各种剂型的可接受性以及他们管理药物的环境,将有助于设计更以患者为中心的药物产品。