Servicio de Otorrinolaringología, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma, Barcelona, Spain.
Servicio de Otorrinolaringología, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma, Barcelona, Spain.
Acta Otorrinolaringol Esp (Engl Ed). 2023 Nov-Dec;74(6):339-345. doi: 10.1016/j.otoeng.2022.10.009. Epub 2023 May 5.
Patients with head and neck squamous cell carcinoma (HNSCC) have an increased risk of second esophageal neoplasms. The aim of the present study is to evaluate the incidence, risk factors and prognosis of second esophageal neoplasms in patients with HNSCC.
A retrospective study of 4711 patients with index tumor in the oral cavity, oropharynx, hypopharynx or larynx between 1985 and 2020 was conducted.
During the period analysed 149 patients (3.2%) had a second esophageal neoplasm. The incidence of second esophageal neoplasia was 0.42% per year and remained nearly constant throughout the follow-up period. According to the results of a multivariate study, the risk factors related to the appearance of second esophageal neoplasms were a history of high alcohol consumption and the location of the primary tumor in the oropharynx or hypopharynx. The 5-year disease-specific survival rate in patients with a second esophageal neoplasm, calculated from the diagnosis of this second neoplasm, was 10.5%.
Patients with a HNSCC have an increased risk of developing of a second esophageal neoplasm. The risk factors associated with the appearance of a second esophageal neoplasm were severe alcohol consumption and the location of the primary tumor in the oropharynx or hypopharynx.
头颈部鳞状细胞癌（HNSCC）患者发生第二食管肿瘤的风险增加。本研究旨在评估 HNSCC 患者第二食管肿瘤的发生率、危险因素和预后。
对 1985 年至 2020 年间口腔、口咽、下咽或喉的指数肿瘤为 4711 例患者进行回顾性研究。
在分析期间，有 149 例（3.2%）患者发生第二食管肿瘤。第二食管肿瘤的发病率为每年 0.42%，在整个随访期间基本保持不变。根据多变量研究的结果，与第二食管肿瘤发生相关的危险因素是高酒精摄入史和原发肿瘤位于口咽或下咽。从第二肿瘤诊断开始计算，第二食管肿瘤患者的 5 年疾病特异性生存率为 10.5%。
HNSCC 患者发生第二食管肿瘤的风险增加。与第二食管肿瘤发生相关的危险因素是严重的酒精摄入和原发肿瘤位于口咽或下咽。
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