Xu Feng, Shen Zhu, Tao Hong, Zhu Zhu, Tao Jia-Long, Feng Zheng-Yang
Department of Pharmacy,the Second Affiliated Hospital of Soochow University,Suzhou,Jiangsu 215004,China.
Department of Oncology,the Second Affiliated Hospital of Soochow University,Suzhou,Jiangsu 215004,China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2023 Apr;45(2):351-354. doi: 10.3881/j.issn.1000-503X.15003.
In recent years,great progress has been achieved in the application of immune checkpoint inhibitors (ICI) in tumor immunotherapy.However,a variety of adverse reactions induced by ICI have been reported.Despite the high overall incidence of adverse reactions caused by ICI,some adverse reactions,such as immune-related pancreatitis,are rare in clinical practice.In this paper,a case of immune-related pancreatitis after treatment of advanced gastric cancer with nivolumab was identified.We analyzed the cause,treatment,incidence,and risk factors of the adverse reaction,aiming to improve the clinical diagnosis,treatment,and safe medication of rare adverse reactions associated with ICI.
近年来，免疫检查点抑制剂（ICI）在肿瘤免疫治疗中的应用取得了巨大进展。然而，已有报道称ICI会引发多种不良反应。尽管ICI引起的不良反应总体发生率较高，但某些不良反应，如免疫相关性胰腺炎，在临床实践中较为罕见。本文报告了1例经纳武利尤单抗治疗晚期胃癌后发生免疫相关性胰腺炎的病例。我们分析了该不良反应的原因、治疗、发生率及危险因素，旨在提高与ICI相关的罕见不良反应的临床诊断、治疗及安全用药水平。
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