先前感染过 SARS-CoV-2 与儿童和青少年的乳糜泻自身免疫无关。
Previous SARS-CoV-2 Infection Is Not Associated With Increased Celiac Disease Autoimmunity in Children and Adolescents.
机构信息
Digestive Health Institute, Children's Hospital Colorado, University of Colorado, Aurora, Colorado, USA.
Barbara Davis Center for Diabetes, University of Colorado, Aurora, Colorado, USA.
出版信息
Am J Gastroenterol. 2023 Sep 1;118(9):1698-1700. doi: 10.14309/ajg.0000000000002317. Epub 2023 Jun 9.
INTRODUCTION
Recent reports suggest severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections may increase the risk of celiac disease autoimmunity. This study aims to evaluate potential associations between coronavirus disease 2019 infection and tissue transglutaminase autoantibodies (TGA) immunoglobulin A.
METHODS
From 2020 to 2021, cross-sectional screening for SARS-CoV-2 antibodies and TGA was offered to 4,717 children in Colorado through the Autoimmunity Screening for Kids study. Multivariable logistic regression assessed association between previous SARS-CoV-2 infection and TGA positivity.
RESULTS
Previous SARS-CoV-2 infection was not associated with TGA positivity (odds ratio 1.02, 95% confidence interval 0.63-1.59; P = 0.95).
DISCUSSION
In this large-scale analysis, previous SARS-CoV-2 infection was not associated with celiac disease autoimmunity in Colorado children.
简介
最近的报告表明，严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染可能会增加乳糜泻自身免疫的风险。本研究旨在评估 2019 年冠状病毒病（COVID-19）感染与组织转谷氨酰胺酶自身抗体（TGA）免疫球蛋白 A 之间的潜在关联。
方法
2020 年至 2021 年，通过 Autoimmunity Screening for Kids 研究向科罗拉多州的 4717 名儿童提供了针对 SARS-CoV-2 抗体和 TGA 的横断面筛查。多变量逻辑回归评估了既往 SARS-CoV-2 感染与 TGA 阳性之间的关联。
结果
既往 SARS-CoV-2 感染与 TGA 阳性无关（比值比 1.02，95%置信区间 0.63-1.59；P=0.95）。
讨论
在这项大规模分析中，科罗拉多州儿童既往 SARS-CoV-2 感染与乳糜泻自身免疫无关。
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