Department of Internal Medicine, Inje University Ilsan Paik Hospital, 170 Juhwa-ro, Ilsanseo-gu, Goyang-si, Gyeonggi-do, 10380, Republic of Korea.
Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 10408, Republic of Korea.
J Gastroenterol. 2023 Jul;58(7):682-692. doi: 10.1007/s00535-023-01999-4. Epub 2023 May 17.
There are no longitudinal studies on the epidemiology of primary biliary cholangitis (PBC) in Korea. This study aimed to elucidate the temporal trends in the epidemiology and outcomes of PBC in South Korea between 2009 and 2019.
The epidemiology and outcomes of PBC were estimated using data from the Korean National Health Service database. Temporal trends in the PBC incidence and prevalence were analyzed using join-point regression. Transplant-free survival was analyzed according to age, sex, and ursodeoxycholic acid (UDCA) treatment using Kaplan-Meier and Cox regression analyses.
The age and sex-standardized incidence between 2010 and 2019 (total patients, 4230) was 1.03 per 100,000 per year on average and increased from 0.71 to 1.14 per 100,000 with an annual percent change (APC) of 5.5. The age and sex-standardized prevalence between 2009 and 2019 was 8.21 per 100,000 on average and increased from 4.30 to 12.32 per 100,000 with an APC of 10.9. The increasing trend in prevalence was prominent in males and elderly individuals. Among patients with PBC, 98.2% received UDCA with 77.3% adherence. The 5-year transplant-free overall survival rate was 87.8%. Male sex and low adherence to UDCA were associated with all-cause death or transplantation (hazard ratios of 1.59 and 1.89, respectively), and liver-related death or transplantation (hazard ratios of 1.43 and 1.87, respectively).
The incidence and prevalence of PBC in Korea increased significantly between 2009 and 2019. Male sex and low adherence to UDCA were poor prognostic factors for PBC.
韩国尚无原发性胆汁性胆管炎（PBC）流行病学的纵向研究。本研究旨在阐明 2009 年至 2019 年期间韩国 PBC 的流行病学和结局的时间趋势。
使用韩国国家卫生服务数据库的数据估算 PBC 的流行病学和结局。使用 join-point 回归分析 PBC 发病率和患病率的时间趋势。使用 Kaplan-Meier 和 Cox 回归分析根据年龄、性别和熊去氧胆酸（UDCA）治疗分析无移植生存率。
2010 年至 2019 年的年龄和性别标准化发病率（总患者 4230 人）平均为每年每 100000 人 1.03 例，从 0.71 增加到 1.14 例，年变化百分比（APC）为 5.5。2009 年至 2019 年的年龄和性别标准化患病率平均为每年每 100000 人 8.21 例，从 4.30 增加到 12.32 例，APC 为 10.9。患病率的上升趋势在男性和老年人中更为明显。在 PBC 患者中，98.2%接受 UDCA 治疗，其中 77.3%的患者坚持治疗。5 年无移植总体生存率为 87.8%。男性和低 UDCA 依从性与全因死亡或移植（危险比分别为 1.59 和 1.89）以及肝相关死亡或移植（危险比分别为 1.43 和 1.87）相关。
韩国 PBC 的发病率和患病率在 2009 年至 2019 年间显著增加。男性和低 UDCA 依从性是 PBC 的不良预后因素。
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