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基于长度和序列的 STRs 在法医标记物中的一致性及其应用指南。

The concordance of length- and sequence-based STRs used in forensic markers with guidance for practice.

机构信息

Department of Forensic Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Forensic Genetic Research Unit, Ratchadapiseksompotch Fund, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Faculty of Criminology and Justice Administration, Rangsit University, Pathum Thani, Thailand.

出版信息

Forensic Sci Int. 2023 Jul;348:111729. doi: 10.1016/j.forsciint.2023.111729. Epub 2023 May 13.

Abstract

Next-generation sequencing (NGS) technology has shed light on every aspect of genetic discoveries, including forensic genetics. The Miseq® FGx Forensic Genetic System (Verogen) is one of the pioneering forensic NGS that provided a complete system from library preparation to data analysis. The system has been validated by several studies and led to a more practical aspect. Short tandem repeat (STR) is a well-established marker that was designed specifically for human individualization. Since NGS provides different data from fragment analysis, a new STR nomenclature is established to make NGS backward compatible with the previous data. In this study, Thai population were used to evaluate the Miseq® FGx Forensic genetic system (Verogen) in practical aspect, including concordance study and forensic population parameters. In summary, we purposed a practical guideline for sequence-based STRs.

摘要

下一代测序(NGS)技术揭示了遗传发现的各个方面,包括法医学遗传学。Miseq® FGx 法医遗传系统(Verogen)是开拓性法医 NGS 技术之一,提供了从文库制备到数据分析的完整系统。该系统已经通过多项研究得到验证,并具有更实际的意义。短串联重复序列(STR)是一种经过充分验证的标记,专门用于人类个体识别。由于 NGS 提供的片段分析数据不同,因此建立了新的 STR 命名法,使 NGS 与以前的数据向后兼容。在这项研究中,泰国人群用于评估 Miseq® FGx 法医遗传系统(Verogen)在实际方面的性能,包括一致性研究和法医人群参数。总之,我们提出了基于序列的 STR 的实用指南。

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